专利检索 ap:("Bio-Rad Laboratories, Inc." OR "CALIFORNIA INSTITUTE OF TECHNOLOGY") AND inv:"Bennett, Melanie" 第 1 页

1.

发明公开
Peptides and peptide analogues designed from the HFE protein and their uses in the treatment of iron overload diseases 审中-公开
标题翻译：在HFE蛋白开发的肽和肽类似物及其用途的基础铁过剩症的治疗

公开(公告)号：EP1859805A3

公开(公告)日：2009-07-01

申请号：EP06022921.8

申请日：1999-12-10

申请人： Bio-Rad Laboratories, Inc. , CALIFORNIA INSTITUTE OF TECHNOLOGY

发明人： Feder, John N. , Schatzman, Randall C. , Bjorkman, Pamela J. , Bennett, Melanie , Lebron, Jose

IPC分类号： A61K38/03 , A61K38/04 , A61K38/10 , C07K7/04 , C07K7/08

CPC分类号： C07K14/70539 , A61K38/00

摘要： The present invention relates to peptides and peptide analogues designed from HFE protein. In particular, it relates to peptides and peptide analogues designed from an alpha-1 region of HFE protein which lowers the binding affinity of transferrin receptor for transferrin. Such compounds mimic HFE protein function, and reduce iron uptake and/or accumulation by a cell.

2.

发明公开
Peptides and peptide analogues designed from the HFE protein and their uses in the treatment of iron overload diseases 审中-公开
标题翻译：在HFE蛋白开发的肽和肽类似物及其用途的基础铁过剩症的治疗

公开(公告)号：EP1859805A2

公开(公告)日：2007-11-28

申请号：EP06022921.8

申请日：1999-12-10

申请人： Bio-Rad Laboratories, Inc. , CALIFORNIA INSTITUTE OF TECHNOLOGY

发明人： Feder, John N. , Schatzman, Randall C. , Bjorkman, Pamela J. , Bennett, Melanie , Lebron, Jose

IPC分类号： A61K38/03 , A61K38/04 , A61K38/10 , C07K7/04 , C07K7/08

CPC分类号： C07K14/70539 , A61K38/00

摘要： The present invention relates to peptides and peptide analogues designed from HFE protein. In particular, it relates to peptides and peptide analogues designed from an alpha-1 region of HFE protein which lowers the binding affinity of transferrin receptor for transferrin. Such compounds mimic HFE protein function, and reduce iron uptake and/or accumulation by a cell.

摘要翻译： 本发明涉及从蛋白质HFE设计的肽和肽类似物。特别是，它涉及由HFE蛋白质的α-1区域这降低了运铁蛋白运铁蛋白受体的结合亲和力设计的肽和肽类似物。搜索化合物模仿HFE蛋白质功能，并通过细胞减少的铁摄取和/或累积。