公开(公告)号：EP3828173A1

公开(公告)日：2021-06-02

申请号：EP20191747.3

申请日：2015-03-09

申请人： BioCryst Pharmaceuticals, Inc.

发明人： KOTIAN, Pravin L. ,  BABU, Yarlagadda S. ,  WU, Minwan ,  CHINTAREDDY, Venkat R ,  KUMAR, Satish V ,  ZHANG, Weihe

IPC分类号： C07D231/14 ,  A61K31/415

摘要： Disclosed are compounds of formula (I), as described herein, and pharmaceutically acceptable salts thereof. The compounds are inhibitors of plasma kallikrein. Also provided are pharmaceutical compositions comprising at least one compound of the invention, and methods involving use of the compounds and compositions of the invention and the treatment and prevention of diseases and conditions characterized by unwanted plasma kallikrein activity.

公开(公告)号：EP4180424A1

公开(公告)日：2023-05-17

申请号：EP22191079.7

申请日：2015-03-09

申请人： BioCryst Pharmaceuticals, Inc.

发明人： KOTIAN, Pravin L. ,  BABU, Yarlagadda S. ,  WU, Minwan ,  KUMAR, Satish V ,  ZHANG, Weihe ,  CHINTAREDDY, Venkat R

IPC分类号： C07D231/14 ,  C07D403/04 ,  C07D403/14 ,  A61K31/415

摘要： Disclosed are compounds of formula I

as described herein, and pharmaceutically acceptable salts thereof. The compounds are inhibitors of plasma kallikrein. Also provided are pharmaceutical compositions comprising at least one compound of the invention, and methods involving use of the compounds and compositions of the invention in the treatment and prevention of diseases and conditions characterized by unwanted plasma kallikrein activity.