公开(公告)号：EP2366709A1

公开(公告)日：2011-09-21

申请号：EP10002775.4

申请日：2010-03-16

申请人： BioNTech AG ,  Universitätsmedizin der Johannes Gutenberg-Universität Mainz

发明人： Klamp, Thorsten ,  Sahin, Ugur ,  Türeci,Özlem ,  Koslowski, Michael ,  Hiller, Thomas ,  Schumacher, Jens

IPC分类号： C07K14/02 ,  A61K39/29 ,  C07K14/47

CPC分类号： C07K14/4748 ,  A61K39/0011 ,  A61K2039/5256 ,  A61K2039/6075 ,  C07K14/005 ,  C07K2319/00 ,  C12N7/00 ,  C12N2730/10122 ,  C12N2730/10123

摘要： The present invention relates to tumor immunotherapy, in particular to tumor vaccination, using chimeric proteins comprising all or a portion of a hepatitis B virus core antigen protein and an amino acid sequence comprising an epitope derived from the extracellular portion of a tumor-associated antigen. In particular, the present invention provides virus-like particles comprising said chimeric proteins, which are useful for eliciting a humoral immune response in a subject against the tumor-associated antigen, in particular against cells carrying said tumor-associated antigen on their surface, wherein the tumor-associated antigen is a self-protein in said subject.

摘要翻译： 本发明涉及使用包含全部或部分乙型肝炎病毒核心抗原蛋白的嵌合蛋白和包含衍生自肿瘤相关抗原的细胞外部分的表位的氨基酸序列的肿瘤免疫治疗，特别是肿瘤免疫治疗。 特别地，本发明提供了包含所述嵌合蛋白的病毒样颗粒，其可用于在受试者中针对肿瘤相关抗原，特别是针对在其表面上携带所述肿瘤相关抗原的细胞引起体液免疫应答，其中 肿瘤相关抗原是所述受试者的自身蛋白质。