公开(公告)号：EP3858333A1

公开(公告)日：2021-08-04

申请号：EP21151194.4

申请日：2018-10-18

申请人： BioNTech RNA Pharmaceuticals GmbH

发明人： HAAS, Heinrich ,  HÖRNER, Sebastian ,  ESPARZA BORQUEZ, Isaac Hernan ,  HILLER, Thomas Michael ,  BATES, Ferdia

IPC分类号： A61K9/127 ,  A61K31/713 ,  A61K9/08 ,  A61K47/26

摘要： The present disclosure relates to methods for preparing RNA lipoplex particles for delivery of RNA to target tissues after parenteral administration, in particular after intravenous administration, and compositions comprising such RNA lipoplex particles. The present disclosure also relates to methods which allow preparing RNA lipoplex particles in an industrial GMP-compliant manner. Furthermore, the present disclosure relates to methods and compositions for storing RNA lipoplex particles without substantial loss of the product quality and, in particular, without substantial loss of RNA activity.

公开(公告)号：EP3697384A1

公开(公告)日：2020-08-26

申请号：EP18792901.3

申请日：2018-10-18

申请人： BioNTech RNA Pharmaceuticals GmbH

发明人： HAAS, Heinrich ,  HÖRNER, Sebastian ,  ESPARZA BORQUEZ, Isaac Hernan ,  HILLER, Thomas Michael ,  BATES, Ferdia

IPC分类号： A61K9/127 ,  A61K31/713