专利检索 ap:("Bioferma Murcia, S.A.") AND inv:"LOPEZ-MAS, Jose AnicetoC/Antonio Sansano Franco" 第 1 页

1.

发明公开
ENZYMATIC PROCESS FOR PREPARING CEPHALOSPORIN DERIVATIVES 审中-公开
标题翻译：酶解过程用于生产头孢菌素衍生物

公开(公告)号：EP1381690A2

公开(公告)日：2004-01-21

申请号：EP02745246.5

申请日：2002-04-18

申请人： Bioferma Murcia, S.A.

发明人： SANCHEZ-FERRER, Alvaro , LOPEZ-MAS, Jose AnicetoC/Antonio Sansano Franco , GARCIA-CARMONA, Francisco

IPC分类号： C12P35/02 , C07D501/18 , C12P35/06 , C07D501/04 , C07D501/36

CPC分类号： C07D501/00

摘要： An enzymatic process for preparing 3-thiolated 7-aminocephalosporanic acid derivatives comprises the steps of enzymatically converting a 3-thiolated cephalosporin C of the formula (I), to form a 3-thiolated-glutaryl-7-ACA of the formula (II) and enzymatically converting a compound of formula (II) to form a 3-thiolated-7-ACA of the formula (III) wherein R is a heterocyclic group comprising at least one nitrogen atom and R1 And R2 are both hydrogen atoms or one of them is a hydrogen atom and the other is an acyl donor.