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公开(公告)号：EP2301577A2
公开(公告)日：2011-03-30
申请号：EP10181803.7
申请日：2003-04-09
申请人： Biogen Idec MA Inc.
CPC分类号： C07K16/241 , A01K2217/05 , A61K38/00 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K14/525 , C07K14/70575 , C07K16/22 , C07K16/2875 , C07K2319/00 , C07K2319/30
摘要： The present invention provides methods and agents for the treatment of TWEAK-related conditions, including cardiac, liver, kidney, lung, adipose, skeletal, muscle, neuronal, bone and cartilage conditions. The invention also provides methods for identifying TWEAK agonists or antagonists for the treatment of TWEAK-related conditions. Additionally, the invention provides transgenic animals that express an exogenous DNA encoding a TWEAK polypeptide, or fragments, analogs, or muteins thereof, and methods for using such animals to identify TWEAK agonists or antagonists. The invention further provides methods for diagnosing a disease based on TWEAK expression. The invention also provides methods for affecting cellular differentiation of progenitor cells using TWEAK polypeptides, agonists, or antagonists.
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公开(公告)号：EP2529619A3
公开(公告)日：2013-04-03
申请号：EP12171177.4
申请日：2006-02-17
申请人： Biogen Idec MA Inc.
CPC分类号： A61K39/3955 , A61K38/1793 , G01N33/6896 , G01N2800/2814 , G01N2800/2835
摘要： Methods of treating neuronal disorders, such as mechanical neuronal traumas and neurodegenerative disorders, with TWEAK or a TWEAK receptor blocking agents are presented.
摘要翻译： 介绍了用TWEAK或TWEAK受体阻断剂治疗神经元病症的方法，例如机械性神经创伤和神经退行性病症。
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公开(公告)号：EP1997512A2
公开(公告)日：2008-12-03
申请号：EP08104327.5
申请日：2003-04-09
申请人： Biogen Idec MA Inc.
CPC分类号： C07K16/241 , A01K2217/05 , A61K38/00 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K14/525 , C07K14/70575 , C07K16/22 , C07K16/2875 , C07K2319/00 , C07K2319/30
摘要： The present invention provides methods and agents for the treatment of TWEAK-related conditions, including cardiac, liver, kidney, lung, adipose, skeletal, muscle, neuronal, bone and cartilage conditions. The invention also provides methods for identifying TWEAK agonists or antagonists for the treatment of TWEAK-related conditions. Additionally, the invention provides transgenic animals that express an exogenous DNA encoding a TWEAK polypeptide, or fragments, analogs, or muteins thereof, and methods for using such animals to identify TWEAK agonists or antagonists. The invention further provides methods for diagnosing a disease based on TWEAK expression. The invention also provides methods for affecting cellular differentiation of progenitor cells using TWEAK polypeptides, agonists, or antagonists.
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公开(公告)号：EP2529619A2
公开(公告)日：2012-12-05
申请号：EP12171177.4
申请日：2006-02-17
申请人： Biogen Idec MA Inc.
CPC分类号： A61K39/3955 , A61K38/1793 , G01N33/6896 , G01N2800/2814 , G01N2800/2835
摘要： Methods of treating neuronal disorders, such as mechanical neuronal traumas and neurodegenerative disorders, with TWEAK or a TWEAK receptor blocking agents are presented.
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公开(公告)号：EP2301578A3
公开(公告)日：2012-08-08
申请号：EP10181810.2
申请日：2003-04-09
申请人： Biogen Idec MA Inc.
CPC分类号： C07K16/241 , A01K2217/05 , A61K38/00 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K14/525 , C07K14/70575 , C07K16/22 , C07K16/2875 , C07K2319/00 , C07K2319/30
摘要： The present invention provides methods and agents for the treatment of TWEAK-related conditions, including cardiac, liver, kidney, lung, adipose, skeletal, muscle, neuronal, bone and cartilage conditions. The invention also provides methods for identifying TWEAK agonists or antagonists for the treatment of TWEAK-related conditions. Additionally, the invention provides transgenic animals that express an exogenous DNA encoding a TWEAK polypeptide, or fragments, analogs, or muteins thereof, and methods for using such animals to identify TWEAK agonists or antagonists. The invention further provides methods for diagnosing a disease based on TWEAK expression. The invention also provides methods for affecting cellular differentiation of progenitor cells using TWEAK polypeptides, agonists, or antagonists.
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公开(公告)号：EP1997512A3
公开(公告)日：2009-03-11
申请号：EP08104327.5
申请日：2003-04-09
申请人： Biogen Idec MA Inc.
CPC分类号： C07K16/241 , A01K2217/05 , A61K38/00 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K14/525 , C07K14/70575 , C07K16/22 , C07K16/2875 , C07K2319/00 , C07K2319/30
摘要： The present invention provides methods and agents for the treatment of TWEAK-related conditions, including cardiac, liver, kidney, lung, adipose, skeletal, muscle, neuronal, bone and cartilage conditions. The invention also provides methods for identifying TWEAK agonists or antagonists for the treatment of TWEAK-related conditions. Additionally, the invention provides transgenic animals that express an exogenous DNA encoding a TWEAK polypeptide, or fragments, analogs, or muteins thereof, and methods for using such animals to identify TWEAK agonists or antagonists. The invention further provides methods for diagnosing a disease based on TWEAK expression. The invention also provides methods for affecting cellular differentiation of progenitor cells using TWEAK polypeptides, agonists, or antagonists.
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公开(公告)号：EP1997512B1
公开(公告)日：2013-12-04
申请号：EP08104327.5
申请日：2003-04-09
申请人： Biogen Idec MA Inc.
CPC分类号： C07K16/241 , A01K2217/05 , A61K38/00 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K14/525 , C07K14/70575 , C07K16/22 , C07K16/2875 , C07K2319/00 , C07K2319/30
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公开(公告)号：EP2332408B1
公开(公告)日：2013-11-13
申请号：EP10194040.1
申请日：2006-02-17
申请人： Biogen Idec MA Inc.
CPC分类号： A61K39/3955 , A61K38/1793 , G01N33/6896 , G01N2800/2814 , G01N2800/2835
摘要： Methods of treating neuronal disorders, such as mechanical neuronal traumas and neurodegenerative disorders, with TWEAK or a TWEAK receptor blocking agents are presented.
摘要翻译： 提出了用TWEAK或TWEAK受体阻断剂治疗神经元疾病如机械神经元创伤和神经变性疾病的方法。
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公开(公告)号：EP2301577A3
公开(公告)日：2012-08-08
申请号：EP10181803.7
申请日：2003-04-09
申请人： Biogen Idec MA Inc.
CPC分类号： C07K16/241 , A01K2217/05 , A61K38/00 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K14/525 , C07K14/70575 , C07K16/22 , C07K16/2875 , C07K2319/00 , C07K2319/30
摘要： The present invention provides methods and agents for the treatment of TWEAK-related conditions, including cardiac, liver, kidney, lung, adipose, skeletal, muscle, neuronal, bone and cartilage conditions. The invention also provides methods for identifying TWEAK agonists or antagonists for the treatment of TWEAK-related conditions. Additionally, the invention provides transgenic animals that express an exogenous DNA encoding a TWEAK polypeptide, or fragments, analogs, or muteins thereof, and methods for using such animals to identify TWEAK agonists or antagonists. The invention further provides methods for diagnosing a disease based on TWEAK expression. The invention also provides methods for affecting cellular differentiation of progenitor cells using TWEAK polypeptides, agonists, or antagonists.
摘要翻译： 本发明提供用于治疗TWEAK相关病症（包括心脏，肝脏，肾脏，肺脏，脂肪，骨骼，肌肉，神经元，骨骼和软骨病症）的方法和药剂。 本发明还提供了鉴定用于治疗TWEAK相关病症的TWEAK激动剂或拮抗剂的方法。 此外，本发明提供了表达编码TWEAK多肽的外源DNA或其片段，类似物或突变蛋白的转基因动物，以及使用这些动物鉴定TWEAK激动剂或拮抗剂的方法。 本发明进一步提供了基于TWEAK表达诊断疾病的方法。 本发明还提供了使用TWEAK多肽，激动剂或拮抗剂来影响祖细胞的细胞分化的方法。
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公开(公告)号：EP2332408A1
公开(公告)日：2011-06-15
申请号：EP10194040.1
申请日：2006-02-17
申请人： Biogen Idec MA Inc.
CPC分类号： A61K39/3955 , A61K38/1793 , G01N33/6896 , G01N2800/2814 , G01N2800/2835
摘要： Methods of treating neuronal disorders, such as mechanical neuronal traumas and neurodegenerative disorders, with TWEAK or a TWEAK receptor blocking agents are presented.
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