公开(公告)号：EP1490110B1

公开(公告)日：2012-06-13

申请号：EP03755325.2

申请日：2003-03-13

申请人： Biogen Idec MA Inc. ,  The Regents of The University of California

发明人： VIOLETTE, Shelia, M. ,  WEINREB, Paul, H. ,  SIMON, Kenneth, J. ,  SHEPPARD, Dean ,  LEONE, Diane, R.

IPC分类号： C07K16/28 ,  A61K39/395 ,  A61K47/48 ,  A61P17/06 ,  A61P35/00 ,  A61P13/12 ,  A61P11/00 ,  A61P1/16 ,  G01N33/577 ,  C12N15/13 ,  C12N5/20

CPC分类号： C07K16/2839 ,  A61K47/48507 ,  A61K47/48561 ,  A61K47/48623 ,  A61K47/68 ,  A61K47/6835 ,  A61K47/6849 ,  A61K47/6851 ,  A61K47/6865 ,  A61K51/1027 ,  A61K51/1066 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92 ,  G01N33/57492 ,  G01N33/6893 ,  G01N2333/70546 ,  G01N2800/085 ,  G01N2800/205

摘要： A monoclonal antibody or an antigen binding fragment thereof that (a) specifically binds to ±v²6 but does not bind other av integrins; and (b) does not inhibit the binding of ²6 to latency associated peptide (LAP) with an IC50 value lower than that of 10D5. Said monoclonal antibody, wherein the antibody comprises a) the same heavy and light chain polypeptide sequences as an antibody produced by hybridoma 6. 2A1 (ATCC accession number PTA-3896) or b) the same heavy and light chain polypeptide sequences as an antibody produced by hybridoma 6.2E5 (ATCC accession number PTA-3897). The disclosure also relates to uses of same and to compositions comprising same.

摘要翻译： （a）特异性结合±v26但不结合其他av整合素的单克隆抗体或其抗原结合片段; 和（b）不抑制结合26与潜伏相关肽（LAP）的结合，IC 50值低于10D5。 所述单克隆抗体，其中所述抗体包含a）与由杂交瘤6 2A1（ATCC登录号PTA-3896）产生的抗体相同的重链和轻链多肽序列或b）与所产生的抗体相同的重链和轻链多肽序列 通过杂交瘤6.2E5（ATCC登录号PTA-3897）。 本公开还涉及其用途和包含其的组合物。

公开(公告)号：EP1490110A2

公开(公告)日：2004-12-29

申请号：EP03755325.2

申请日：2003-03-13

申请人： Biogen Idec MA Inc. ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： VIOLETTE, Shelia, M. ,  WEINREB, Paul, H. ,  SIMON, Kenneth, J. ,  SHEPPARD, Dean ,  LEONE, Diane, R.

IPC分类号： A61K39/395 ,  C07K16/28 ,  C12N5/12

CPC分类号： C07K16/2839 ,  A61K47/48507 ,  A61K47/48561 ,  A61K47/48623 ,  A61K47/68 ,  A61K47/6835 ,  A61K47/6849 ,  A61K47/6851 ,  A61K47/6865 ,  A61K51/1027 ,  A61K51/1066 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92 ,  G01N33/57492 ,  G01N33/6893 ,  G01N2333/70546 ,  G01N2800/085 ,  G01N2800/205

摘要： A monoclonal antibody or an antigen binding fragment thereof that (a) specifically binds to ±v²6 but does not bind other av integrins; and (b) does not inhibit the binding of ²6 to latency associated peptide (LAP) with an IC50 value lower than that of 10D5. Said monoclonal antibody, wherein the antibody comprises a) the same heavy and light chain polypeptide sequences as an antibody produced by hybridoma 6. 2A1 (ATCC accession number PTA-3896) or b) the same heavy and light chain polypeptide sequences as an antibody produced by hybridoma 6.2E5 (ATCC accession number PTA-3897). The disclosure also relates to uses of same and to compositions comprising same.

摘要翻译： 与αvβ6特异性结合的单克隆抗体。 还包括使用这些抗体治疗患有或有风险患有αvβ6介导的疾病或诊断αvβ6介导的疾病的哺乳动物的方法。

公开(公告)号：EP2087008A1

公开(公告)日：2009-08-12

申请号：EP07875049.4

申请日：2007-10-16

申请人： The Regents of the University of California ,  Biogen Idec MA Inc.

发明人： SHEPPARD, Dean ,  HUANG, Xiaozhu ,  VIOLETTE, Sheila, M.

IPC分类号： C07K16/28 ,  A61K39/395 ,  A61P11/06

CPC分类号： C07K16/2839 ,  A01K67/0276 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/0368 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/56 ,  C07K2317/565

摘要： The present invention relates to methods of asthma treatment and prevention using αvβ6 antagonists, such as αvβ6-binding antibodies. In particular, the invention relates to the discovery of a correlation between reduced expression of αvβ6 and the protection from the increase in airway sensitivity seen in chronic allergen-challenged mice. This protection is associated with protection from the usual allergen-induced increase in airway epithelial mast cells.

公开(公告)号：EP2831104A1

公开(公告)日：2015-02-04

申请号：EP13768248.0

申请日：2013-03-15

申请人： Biogen Idec MA Inc. ,  The Regents of the University of California

发明人： VIOLETTE, Shelia M. ,  SHEPPARD, Dean

IPC分类号： C07K14/495

CPC分类号： C12Q1/6876 ,  C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/158 ,  G01N33/6893 ,  G01N2333/495 ,  G01N2333/70546 ,  G01N2800/52

摘要： The present invention relates to biomarkers for use in determining the sensitivity of patients to therapy with αvβ6 integrin inhibition or therapy with TGF-β pathway inhibitors. The biomarker profiles disclosed herein provide individualized gene and protein profiles which will aid in treating diseases and disorders which are amenable to treatment with therapies designed against αvβ6-integrin and/or TGF-β pathway inhibitors.

摘要翻译： 本发明涉及用于确定患者对用αvβ6整联蛋白抑制剂治疗或用TGF-β途径抑制剂治疗的敏感性的生物标志物。 本文公开的生物标志物谱提供了个体化的基因和蛋白质谱，其将有助于治疗适合用针对αvβ6-整联蛋白和/或TGF-β途径抑制剂设计的疗法治疗的疾病和病症。

公开(公告)号：EP4284520A1

公开(公告)日：2023-12-06

申请号：EP22746474.0

申请日：2022-01-25

申请人： The Regents of the University of California

发明人： SHEPPARD, Dean ,  BIDLINGMAIER, Scott ,  LIU, Bin ,  ATAKILIT, Amha

IPC分类号： A61P35/04 ,  C07K16/28 ,  C07K16/30

公开(公告)号：EP3765005A1

公开(公告)日：2021-01-20

申请号：EP19766565.6

申请日：2019-03-13

申请人： The Regents of the University of California

发明人： SHEPPARD, Dean ,  SUNDARAM, Aparna ,  DEGRADO, William, F. ,  JO, Hyunil

IPC分类号： A61K31/17 ,  C07C275/16 ,  C07C275/24

公开(公告)号：EP2981554B1

公开(公告)日：2020-07-29

申请号：EP14778764.2

申请日：2014-04-01

申请人： The Regents of the University of California

发明人： SHEPPARD, Dean ,  ATAKILIT, Amha ,  HENDERSON, Neil Cowan

IPC分类号： C07K16/28

公开(公告)号：EP3847194A1

公开(公告)日：2021-07-14

申请号：EP19772925.4

申请日：2019-09-05

申请人： Pfizer Inc. ,  The Regents of the University of California

发明人： NIESSEN, Kyle, Steven ,  SAMUEL, Dharmaraj ,  HOLST, Charles, Ray ,  DREVER, Matthew, Ross ,  SHEPPARD, Dean ,  AKHURST, Rosemary, J. ,  ATAKILIT, Amha ,  MEYER, Dominique ,  RONDON, Isaac, J. ,  DAL PORTO, Joseph

IPC分类号： C07K16/28 ,  A61P35/00

公开(公告)号：EP3436046A2

公开(公告)日：2019-02-06

申请号：EP17776794.4

申请日：2017-03-31

申请人： The Regents of the University of California

发明人： SHEPPARD, Dean ,  SUNDARAM, Aparna ,  DEGRADO, William, F. ,  JO, Hyunil ,  MCINTOSH, Joel

IPC分类号： A61K38/05 ,  C07D403/12 ,  C07D413/12

公开(公告)号：EP2981554A2

公开(公告)日：2016-02-10

申请号：EP14778764.2

申请日：2014-04-01

申请人： The Regents of the University of California

发明人： SHEPPARD, Dean ,  ATAKILIT, Amha ,  HENDERSON, Neil Cowan

IPC分类号： C07K16/28

摘要： Antibodies (e.g., isolated antibodies) that specifically bind to human integrin β8 and inhibit adhesion of latency associated peptide (LAP) to αvβ8 are provided. In some embodiments, the antibody cross-reacts with mouse integrin β8. In some embodiments, the antibody blocks TGFJ3 activation. In some embodiments, the antibody antagonizes binding of LAP to αβ8 with an IC50 below 5 nM.