专利检索 ap:("Biogen Idec MA Inc." OR "University of Miami") AND inv:"Kenyon, Norma S." 第 1 页

1.

发明公开
CD 154 blockage therapy for pancreatic islet tissue transplantation in primates 失效
标题翻译：在灵长类动物中胰岛细胞移植的CD154阻断治疗

公开(公告)号：EP1754490A3

公开(公告)日：2010-01-20

申请号：EP06019551.8

申请日：1998-06-19

申请人： Biogen Idec MA Inc. , University of Miami

发明人： Kenyon, Norma S. , Ricordi, Camillo , Thomas, David W. , Burkly, Linda

IPC分类号： A61K39/395 , A61K38/00 , G01N33/48

CPC分类号： C07K16/2875 , A61K38/00 , A61K2039/505 , C07K2317/76

摘要： The present invention provides methods and compositions for inhibiting rejection of insulin-producing tissue in a graft recipient, as well as methods and compositions for prolonging graft survival or function. The present invention further proves methods for reversing graft rejection or restoring function of an impaired graft and for inducing immunological tolerance to grafted, insulin-producing tissue. The present methods and compositions are suitable for treatment or prophylaxis of defects in metabolic control of blood glucose homeostasis, including defects manifested as diabetes melitus (DM).