公开(公告)号：EP2364089B1

公开(公告)日：2016-12-07

申请号：EP09823937.9

申请日：2009-10-30

申请人： Biogen MA Inc.

发明人： GUCKIAN, Kevin, M. ,  CALDWELL, Richard, D. ,  KUMARAVEL, Gnanasambandam ,  LEE, Wen-cherng ,  LIN, Edward, Yin-shiang ,  LIU, Xiaogao ,  MA, Bin ,  SCOTT, Daniel, M. ,  SHI, Zhan ,  ZHENG, Guo, Zhu ,  TAVERAS, Arthur, G. ,  THOMAS, Jermaine

IPC分类号： A01N47/10 ,  A61K31/22 ,  A61K31/135 ,  A61K31/47 ,  A61K31/4704 ,  A61K31/502 ,  C07C211/30 ,  C07D215/20 ,  C07D239/78 ,  C07D215/227 ,  A61P29/00

CPC分类号： A61K31/135 ,  A61K31/22 ,  C07C217/52 ,  C07C217/74 ,  C07C2602/10 ,  C07D215/20 ,  C07D239/74

公开(公告)号：EP2672823B1

公开(公告)日：2016-08-24

申请号：EP12745253.0

申请日：2012-02-03

申请人： Biogen MA Inc.

发明人： THOMAS, Jermaine ,  MI, Sha ,  LIN, Edward, Yin-shiang ,  ZHENG, Guo, Zhu ,  MA, Bin ,  CALDWELL, Richard, D. ,  GUCKIAN, Kevin ,  KUMARAVEL, Gnanasambandam

IPC分类号： C07D401/06 ,  C07D405/12 ,  C07D211/34 ,  C07D211/60 ,  C07D211/62 ,  A61K31/55 ,  A61P25/00

CPC分类号： A61K31/445 ,  A61K31/225 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/498 ,  A61K31/517 ,  A61K31/55 ,  A61K31/695 ,  A61K38/21 ,  A61K39/3955 ,  C07D211/34 ,  C07D211/60 ,  C07D211/62 ,  C07D215/20 ,  C07D401/06 ,  C07D405/12 ,  C07K16/2842

摘要： Compounds of formula (I) or (II) can modulate the activity of SIP receptors. Compounds of formula (I) or (II) can modulate the activity of SIP receptors.

公开(公告)号：EP4244223A1

公开(公告)日：2023-09-20

申请号：EP21823425.0

申请日：2021-11-12

申请人： Biogen MA Inc.

发明人： HOPKINS, Brian, T. ,  MA, Bin ,  MARX, Isaac ,  SCHULZ, Jurgen ,  VANDEVEER, George ,  PRINCE, Robin ,  NEVALAINEN, Marta ,  CHEN, Teyu ,  YOUSAF, Zain ,  HIMMELBAUER, Martin ,  PATTAROPONG, Vatee ,  JONES, John, Howard ,  LIN, Edward, Yin-shiang ,  GONZALEZ LOPEZ DE TURISO, Felix ,  PURGETT, Thomas ,  CAPACCI, Andrew, George ,  SCIABOLA, Simone

IPC分类号： C07D471/04 ,  C07D487/04 ,  C07D519/00 ,  A61P19/02 ,  A61P35/02 ,  A61K31/4985 ,  A61K31/506 ,  A61P17/00 ,  A61P35/00 ,  A61K31/437

公开(公告)号：EP3660010A1

公开(公告)日：2020-06-03

申请号：EP19203412.2

申请日：2012-02-03

申请人： Biogen MA Inc.

发明人： THOMAS, Jermaine ,  MI, Sha ,  LIN, Edward, Yin-shiang ,  ZHENG, Guo, Zhu ,  MA, Bin ,  CALDWELL, Richard, D. ,  GUCKIAN, Kevin ,  KUMARAVEL, Gnanasambandam

IPC分类号： C07D401/06 ,  C07D405/12 ,  C07D211/34 ,  C07D211/60 ,  C07D211/62 ,  A61K31/55 ,  A61P25/00

摘要： Compounds of formula (I) or (II) can modulate the activity of SIP receptors. Compounds of formula (I) or (II) can modulate the activity of SIP receptors.

公开(公告)号：EP2925721A1

公开(公告)日：2015-10-07

申请号：EP13799458.8

申请日：2013-11-20

申请人： Biogen MA Inc.

发明人： PENG, Hairuo ,  LIN, Edward, Yin-shiang ,  CHAO, Jianhua ,  XIN, Zhili ,  MA, Bin ,  GUCKIAN, Kevin ,  CHAN, Timothy ,  KUMARAVEL, Gnanasambandam ,  TAVERAS, Arthur, G.

IPC分类号： C07D207/08 ,  C07D211/22 ,  C07D211/56 ,  C07D211/62 ,  C07D211/70 ,  C07D213/74 ,  C07D237/22 ,  C07D239/47 ,  C07D295/15 ,  C07D295/155 ,  C07D401/12 ,  A61K31/40 ,  A61K31/451 ,  A61K31/4545 ,  A61K31/495

CPC分类号： C07D211/22 ,  A61K31/451 ,  A61K31/4545 ,  A61K31/495 ,  A61K31/501 ,  A61K31/506 ,  A61K45/06 ,  C07D207/08 ,  C07D211/56 ,  C07D211/62 ,  C07D211/70 ,  C07D213/74 ,  C07D237/22 ,  C07D239/47 ,  C07D295/15 ,  C07D295/155 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04

摘要： Compounds of formula (I) wherein: X is —O—, —S(O)r—, —CH2—, or —NR—, wherein r is 0, 1, or 2; X1, X2, and X5 are each independently CR7 or N; one of X3 or X4 is C and is attached by a single bond to -L-, and the other is CR7 or N, provided that no more than three of X1, X2, X3, X or X5 are N; Ring A is monocyclic C5-6scycloalkyl or a 5- to 6-membered monocyclic heterocyclyl comprising from 1 to 5 heteroatoms independently selected from N, S, or O; wherein Ring A is further optionally substituted with from 1 to 3 R4; provided that Ring A is not morpholinyl, thiomorpholinyl or tetrahydro-2H-pyranyl; L is a bond, —O—, —NR—, —S(O)n—, —CH2—, or —C(O)—, wherein n is 0, 1, or 2; 1 2 L1 is an C1-8alkylene, C3-scycloalkylene, —CH2-L2-, or a 3- to 8-membered heterocyclylene comprising 1 to 5; R1 is C6-20alkyl or a monocyclic C3-8cycloalkyl; wherein said C3-8cycloalkyl is substituted with at least one R6 and may be optionally substituted with from 1 to 5 additional R6 substituents, wherein R6 for each occurrence is independently selected; and R2 is —C(O)OR3, —C(O)N(R3)—S(O)2R3, —S(O)2OR3, —C(O)NHC(O)R3, —Si(O)OH, —B(OH)2, —N(R3)S(O)2R3, —S(O)2N(R3)2, —O—P(O)(OR3)2, or —P(O)(OR3)2, —CN, —S(O)2NHC(O)R3, —C(O)NHS(O)2R3, —C(O)NHOH, —C(O)NHCN, —CH(CF3)OH, —C(CF3)2OH, or a selected heteroaryl or heterocyclyl; and pharmaceutically acceptable salts thereof, can modulate the activity of one or more SIP receptors and/or the activity of autotaxin (ATX).

公开(公告)号：EP3150590B1

公开(公告)日：2019-10-16

申请号：EP16183267.0

申请日：2012-02-03

申请人： Biogen MA Inc.

发明人： THOMAS, Jermaine ,  MI, Sha ,  LIN, Edward, Yin-shiang ,  ZHENG, Guo, Zhu ,  MA, Bin ,  CALDWELL, Richard, D. ,  GUCKIAN, Kevin ,  KUMARAVEL, Gnanasambandam

IPC分类号： C07D401/06 ,  C07D405/12 ,  C07D211/34 ,  C07D211/60 ,  C07D211/62 ,  A61K31/55 ,  A61P25/00