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1.发明公开METHODS FOR OVERCOMING GLUTAMINE DEPRIVATION DURING MAMMALIAN CELL CULTURE 审中-公开VERFAHREN ZURÜBERWINDUNGVON GLUTAMINDEPRIVATION BEI EINERSÄUGETIERZELLKULTUR
公开(公告)号：EP3122869A1
公开(公告)日：2017-02-01
申请号：EP15716252.0
申请日：2015-03-24
发明人： YANG, William , HUANG, Yao-Ming , MARTY, Sinacore , RYLL, Thomas , LU, Jiuyi , LEE, Jaesun , LIM, Hyoung Taek , YANG, Eunchong , LEE, Kyngju
IPC分类号： C12N5/00
CPC分类号： C12N5/0018 , C12N2500/40 , C12N2500/60 , C12P21/00
摘要： The present invention pertains to methods of producing polypeptide of interest in cell cultures lacking glutamine. The present invention further pertains to a method of producing a protein of interest in a large scale cell culture, comprising supplementing the cell culture with nucleic acid synthesis precursors and/or corticosteroids.
摘要翻译： 本发明涉及在缺乏谷氨酰胺的细胞培养物中产生感兴趣多肽的方法。 本发明还涉及在大规模细胞培养物中生产感兴趣的蛋白质的方法，其包括用核酸合成前体和/或皮质类固醇补充细胞培养物。
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公开(公告)号：EP3122869B1
公开(公告)日：2019-06-05
申请号：EP15716252.0
申请日：2015-03-24
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公开(公告)号：EP3533863A1
公开(公告)日：2019-09-04
申请号：EP17864795.4
申请日：2017-10-26
发明人： PARK, Joon Tae , LEE, Kyung Ju , LIM, Joo Song , LIM, Hyoung Taek , HUH, Yun Jeong , LEE, Jae Sun , MIN, Hosung
摘要： Provided are an improved culture process for reducing unwanted culture byproducts when a target protein is produced in a glutamine-free cell culture medium, an improved culture process for producing a target protein in a glutamine-free cell culture medium, or an improved culture process for producing a target protein in a glutamine-free cell culture medium.
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