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公开(公告)号：EP4257610A1
公开(公告)日：2023-10-11
申请号：EP22739046.5
申请日：2022-01-12
发明人： ZHOU, Yali , CHEN, Gong , GUO, Tingting , JIANG, Xiaoyan , REN, Jiangtao , HE, Xiaohong , WANG, Yanbin , HAN, Lu , LI, Guokun , ZHANG, Jing , SUN, Huifang
IPC分类号： C07K16/30 , C12N15/13 , C12N15/63 , A61K39/395 , A61P35/00
摘要： Provided are an ROR1-targeting antibody, and a multispecific antibody, a chimeric antigen receptor, an antibody conjugate, a pharmaceutical composition and a kit which comprise same, and the use thereof in the diagnosis/treatment/prevention of diseases associated with ROR1 expression.
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公开(公告)号：EP4234580A1
公开(公告)日：2023-08-30
申请号：EP21893973.4
申请日：2021-11-18
发明人： ZHOU, Yali , CHEN, Gong , JIANG, Xiaoyan , GUO, Tingting , REN, Jiangtao , HE, Xiaohong , WANG, Yanbin , HAN, Lu
IPC分类号： C07K16/28 , C12N15/13 , C07K16/46 , C12N15/63 , C12N5/10 , C07K19/00 , A61K39/395 , A61P35/00
摘要： Provided are an NKG2A-targeting antibody, and a multispecific antibody, a chimeric receptor, an antibody conjugate, a pharmaceutical composition and a kit which comprise same, and the use thereof in the diagnosis/treatment/prevention of diseases associated with NKG2A expression.
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公开(公告)号：EP4273175A1
公开(公告)日：2023-11-08
申请号：EP21924358.1
申请日：2021-12-07
发明人： ZHOU, Yali , CHEN, Gong , GUO, Tingting , JIANG, Xiaoyan , REN, Jiangtao , HE, Xiaohong , WANG, Yanbin , HAN, Lu
摘要： Provided is a chimeric antigen receptor, comprising an antigen binding region, a transmembrane domain and an intracellular signaling region. The antigen binding region comprises an antibody specifically targeting CD7, and the intracellular signaling region consists of a co-stimulatory domain, a primary signal transduction domain, and a γC chain or intracellular region thereof. Also provided are an engineered immune cell comprising the chimeric antigen receptor and a pharmaceutical composition thereof, and use of the engineered immune cell/pharmaceutical composition for treating cancers.
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