公开(公告)号：EP1977739A1

公开(公告)日：2008-10-08

申请号：EP07380089.8

申请日：2007-04-03

申请人： BIOIBERICA, S.A.

发明人： Escaich Ferrer, Josep ,  Alonso Fernandez, Ma José ,  Vila Pena, Ana Isabel ,  Ruhi Roura, Ramon

IPC分类号： A61K9/51 ,  A61K31/737 ,  A61K31/722 ,  A61K31/738 ,  A61K31/715

CPC分类号： A61K9/5161 ,  A61K9/5192 ,  A61K31/715 ,  A61K31/722 ,  A61K31/737 ,  A61K31/738 ,  A61K2300/00

摘要： The invention relates to a composition comprising nanoparticles with a size of less than 1 micron for the release of chondroitin sulfate, wherein the nanoparticles comprise at least chitosan or a derivative thereof, and at least one chondroitin sulfite or a derivative thereof, and wherein the nanoparticles are crosslinked by means of a crosslinking agent. It also refers to a process for preparing said nanoparticulate composition.

摘要翻译： 本发明涉及包含尺寸小于1微米的用于释放硫酸软骨素的纳米颗粒的组合物，其中纳米颗粒至少包含壳聚糖或其衍生物，以及至少一种硫酸软骨素或其衍生物，并且其中纳米颗粒 通过交联剂进行交联。 它还涉及制备所述纳米颗粒组合物的方法。

公开(公告)号：EP2479257A1

公开(公告)日：2012-07-25

申请号：EP11173781.3

申请日：2007-07-31

申请人： BIOIBERICA, S.A.

发明人： Escaich Ferrer, Josep ,  Ruhi Roura, Ramon ,  Torrent Gibert, Ana Maria

IPC分类号： C12N5/00 ,  A61F2/00

CPC分类号： C12N5/0654 ,  A61K35/12 ,  A61L27/3804 ,  A61L27/3843 ,  C12N5/0655 ,  C12N2500/34 ,  C12N2500/46 ,  C12N2533/74

摘要： "Use of aminosugars and chondrocytes for the treatment of cartilage and osteochondral defects and lesions"
The present invention relates to the use of compositions comprising an aminosugar in combination with chondrocytes, and a biocompatible support matrix for the treatment of cartilage, and osteochondral defects or lesions.

摘要翻译： “氨基糖和软骨细胞的软骨和骨软骨缺损和损伤的治疗中的使用”的本发明涉及在组合使用的组合物包括氨基糖与软骨细胞和软骨的治疗的生物相容载体基质，和骨软骨缺陷或损伤 ，

公开(公告)号：EP2471802A1

公开(公告)日：2012-07-04

申请号：EP10197017.6

申请日：2010-12-27

申请人： Bioiberica, S.A.

发明人： McGuigan, Christopher ,  Caterson, Bruce ,  Alaez Verson, Carlos Raul ,  Torrent Gibert, Ana Maria ,  Ruhi Roura, Ramon ,  Hughes, Clare E. ,  Escaich Ferrer, Josep

IPC分类号： C07H11/04 ,  A61K31/7024 ,  A61P29/00

CPC分类号： C07H11/04 ,  C07H13/04

摘要： The present invention relates novel phosphoramidates of monosaccharides of formula (I), wherein R 1 is a monosaccharide group selected from A and B; R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , R 12 , R 13 , R 14 , R 15 , R 16 and X are as defined herein. Preferably X is -O-. The present invention also provides processes for the production of compounds of formula (I), pharmaceutical compositions comprising these compounds, as well as to the use thereof in medical therapy, preferably in the treatment of osteoarthritis.

wherein:
R 1 is selected from A and B,

摘要翻译： 本发明涉及式（I）单糖的新型氨基磷酸酯，其中R 1为选自A和B的单糖基团; R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9，R 10，R 11，R 12，R 13，R 14，R 15，R 16和X如本文所定义 。 X优选为-O-。 本发明还提供了制备式（I）化合物的方法，包含这些化合物的药物组合物，以及其在药物治疗中的用途，优选用于治疗骨关节炎。 其中：R 1选自A和B，

公开(公告)号：EP2301554A8

公开(公告)日：2011-10-26

申请号：EP10192184.9

申请日：2008-12-17

申请人： Bioiberica, S.A.

发明人： Escaich Ferrer, Josep ,  Torrent Gibert, Ana Maria ,  Ruhi Roura, Ramon ,  Dalmau Castañares, Pere

IPC分类号： A61K31/7008 ,  A61K31/737 ,  A61P19/02

CPC分类号： A61K31/7008 ,  A61K31/737 ,  A61K2300/00

摘要： "Pharmaceutical composition for the treatment of osteoarthritis" The present invention relates to pharmaceutical compositions comprising chondroitin sulphate and an amino sugar, wherein the amino sugar is selected from the group consisting of mannosamine, a mannosamine derivative and mixtures thereof. The mannosamine derivative is preferably N- acetylmannosamine. The pharmaceutical compositions may further comprise glucosamine. Said compositions are disclosed for use as a medicament. In particular, said compositions are useful in the treatment or prevention of degenerative joint diseases, preferably of osteoarthritis, in the treatment or prevention of tendon or ligament diseases, disorders or injuries and of immune system diseases, preferably of rheumatoid arthritis.

公开(公告)号：EP2301554A1

公开(公告)日：2011-03-30

申请号：EP10192184.9

申请日：2008-12-17

申请人： Bioiberica, S.A.

发明人： Escaich Ferrer, Josep ,  Torrent Gibert, Ana Maria ,  Ruhi Roura, Ramon ,  Dalmau Castañares, Pere

IPC分类号： A61K31/7008 ,  A61K31/737 ,  A61P19/02

CPC分类号： A61K31/7008 ,  A61K31/737 ,  A61K2300/00

摘要： "Pharmaceutical composition for the treatment of osteoarthritis" The present invention relates to pharmaceutical compositions comprising chondroitin sulphate and an amino sugar, wherein the amino sugar is selected from the group consisting of mannosamine, a mannosamine derivative and mixtures thereof. The mannosamine derivative is preferably N- acetylmannosamine. The pharmaceutical compositions may further comprise glucosamine. Said compositions are disclosed for use as a medicament. In particular, said compositions are useful in the treatment or prevention of degenerative joint diseases, preferably of osteoarthritis, in the treatment or prevention of tendon or ligament diseases, disorders or injuries and of immune system diseases, preferably of rheumatoid arthritis.

摘要翻译： “用于治疗骨关节炎的药物组合物”本发明涉及包含硫酸软骨素和氨基糖的药物组合物，其中所述氨基糖选自甘露糖胺，甘露糖胺衍生物及其混合物。 甘露糖胺衍生物优选为N-乙酰甘露糖胺。 药物组合物还可以包含葡糖胺。 所述组合物公开用作药物。 特别地，所述组合物可用于治疗或预防退行性关节疾病，优选骨关节炎，治疗或预防腱或韧带疾病，病症或损伤以及免疫系统疾病，优选类风湿性关节炎。