公开(公告)号：EP1778632B1

公开(公告)日：2008-08-20

申请号：EP05751812.8

申请日：2005-06-17

申请人： Biolipox AB

发明人： OLOFSSON, Kristofer Orexo AB ,  SUNA, Edgars ,  PELCMAN, Benjamin Orexo AB ,  OZOLA, Vita ,  KATKEVICS, Martins ,  KALVINS, Ivars

IPC分类号： C07D209/42 ,  C07D401/04 ,  A61K31/404 ,  A61P29/00

CPC分类号： C07D401/04

摘要： There is provided a compound of formula: (I), wherein X, R1, R2, R3, R4, R5 and R6 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of the activity of microsomal prostaglandin E synthase-1 is desired and/or required, and particularly in the treatment of inflammation.

公开(公告)号：EP1933834A1

公开(公告)日：2008-06-25

申请号：EP06794740.8

申请日：2006-10-12

申请人： Biolipox AB

发明人： PELCMAN, Benjamin ,  OLOFSSON, Kristofer ,  SCHAAL, Wesley ,  KALVINS, Ivars ,  KATKEVICS, Martins ,  OZOLA, Vita ,  SUNA, Edgars

IPC分类号： A61K31/423 ,  A61K31/4439 ,  A61K31/497 ,  A61P29/00 ,  A61P11/06 ,  C07D263/56 ,  C07D413/12

CPC分类号： A61K31/423 ,  A61K31/4439 ,  A61K31/497 ,  C07D263/57 ,  C07D413/12

摘要： There is provided the use of a compound of formula (I),wherein Y, W1 to W4, Z1 to Z4 and R have meanings given in the description, and pharmaceutically-acceptable salts thereof, for the manufacture of a medicament for the treatment of a disease in which inhibition of the activity of a member of the MAPEG family is desired and/or required, and particularly in the treatment of inflammation.

公开(公告)号：EP1844013A1

公开(公告)日：2007-10-17

申请号：EP05823716.5

申请日：2005-12-22

申请人： Biolipox AB

发明人： PELCMAN, Benjamin ,  OLOFSSON, Kristofer ,  KATKEVICS, Martins ,  OZOLA, Vita ,  SUNA, Edgars ,  KALVINS, Ivars ,  TRAPENCIERIS, Peteris

IPC分类号： C07D209/42 ,  C07D401/04 ,  A61K31/404 ,  A61P11/00 ,  A61P29/00 ,  C07D405/12 ,  C07D401/12 ,  C07D401/14

CPC分类号： C07D401/04 ,  C07D209/42 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12

摘要： There is provided compounds of formula (I), Wherein X1 , R1 , R2 , R3, R4, R5 and R6 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of the activity of a member of the MAPEG family is desired and/or required, and particularly in the treatment of inflammation.

摘要翻译： 提供式（I）化合物，其中X 1，R 1，R 2，R 3，R 4，R 5和R 6具有说明书中给出的含义，及其药学上可接受的盐，所述化合物可用于治疗其中抑制 希望和/或需要MAPEG家族成员的活性，特别是在炎症的治疗中。

公开(公告)号：EP2102177A1

公开(公告)日：2009-09-23

申请号：EP07848492.0

申请日：2007-12-12

申请人： Boehringer Ingelheim International GmbH ,  Biolipox AB

发明人： PELCMAN, Benjamin ,  OLOFSSON, Kristofer ,  KALVINS, Ivars ,  SUNA, Edgars ,  OZOLA, Vita ,  SCHAAL, Wesley

IPC分类号： C07D263/57 ,  A61K31/423 ,  A61P11/06 ,  A61P29/00

CPC分类号： C07D263/57

摘要： There is provided the use of a compound of formula (I): wherein Y, W1 to W4, Z1 to Z4 and R have meanings given in the description, and pharmaceutically-acceptable salts thereof, for the manufacture of a medicament for the treatment of a disease in which inhibition of the activity of a member of the MAPEG family is desired and/or required, and particularly in the treatment of inflammation.

公开(公告)号：EP1778632A1

公开(公告)日：2007-05-02

申请号：EP05751812.8

申请日：2005-06-17

申请人： Biolipox AB

发明人： OLOFSSON, Kristofer Biolipox AB ,  SUNA, Edgars ,  PELCMAN, Benjamin Biolipox AB ,  OZOLA, Vita ,  KATKEVICS, Martins ,  KALVINS, Ivars

IPC分类号： C07D209/42 ,  C07D401/04 ,  A61K31/404 ,  A61P29/00

CPC分类号： C07D401/04

摘要： There is provided a compound of formula: (I), wherein X, R1, R2, R3, R4, R5 and R6 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of the activity of microsomal prostaglandin E synthase-1 is desired and/or required, and particularly in the treatment of inflammation.

摘要翻译： 提供了式（I）化合物，其中X，R 1，R 2，R 3，R 4，R 5和R 6具有说明书中给出的含义，及其药学上可接受的盐，所述化合物可用于治疗 其中期望和/或需要抑制微粒体前列腺素E合酶-1的活性，特别是在炎症的治疗中。