专利检索 ap:("Biomed Valley Discoveries, Inc." OR "Vertex Pharmaceuticals Incorporated") AND inv:"LITTLER, Benjamin" 第 1 页

1.

发明公开
CRYSTALLINE FORMS OF C21H22CI2N4O2 审中-公开
标题翻译：结晶形式的C 21 H 22 Cl 2 N 4 O 2

公开(公告)号：EP3250562A1

公开(公告)日：2017-12-06

申请号：EP16744240.9

申请日：2016-01-29

申请人： Biomed Valley Discoveries, Inc. , Vertex Pharmaceuticals Incorporated

发明人： DECRESCENZO, Gary , WELSCH, Dean , VLAHOVA, Petinka I. , BOERRIGTER, Stephan X.M. , ARONOV, Alexander , KESHAVARZ-SHOKRI, Ali , SCANGAS, Alexander N. , STAVROPOULOS, Kathy , LITTLER, Benjamin , KADIYALA, Irina Nikolaevna , ALARGOVA, Rossitza Gueorguieva

IPC分类号： C07D401/04

CPC分类号： C07D401/04 , A61K31/4439 , A61K45/06 , A61P35/00

摘要： The present invention provides crystalline forms of a compound of formula (I): Also provided are pharmaceutical compositions that include the provided crystalline forms and methods of using the provided crystalline forms and pharmaceutical compositions for the treatment of cancer.

2.

发明授权
PROCESS FOR PREPARING AZABICYCLIC COMPOUNDS 有权
标题翻译：用于生产的氮杂双环CONNECTIONS

公开(公告)号：EP2477991B1

公开(公告)日：2015-04-15

申请号：EP10757544.1

申请日：2010-09-17

申请人： Vertex Pharmaceuticals Incorporated

发明人： AMBHAIKAR, Narendra, Bhalchandra , BEAR, Brian, Richard , FANNING, Lev, T., D. , HUGHES, Robert , LITTLER, Benjamin

IPC分类号： C07D487/08

CPC分类号： C07D487/08

3.

发明公开
PROCESS FOR PREPARING MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR 审中-公开
标题翻译：用于制备本调节器的调节剂跨膜电导AT囊性纤维化

公开(公告)号：EP2491018A1

公开(公告)日：2012-08-29

申请号：EP10775986.2

申请日：2010-10-21

申请人： Vertex Pharmaceuticals Incorporated

发明人： AMBHAIKAR, Narendra, Bhalchandra , HUGHES, Robert , HURLEY, Dennis, James , LEE, Elaine, Chungmin , LITTLER, Benjamin , NUMA, Mehdi , ROEPER, Stefanie , SHETH, Urvi

IPC分类号： C07D215/56 , C07D487/08

CPC分类号： C07D487/08 , C07D215/56

摘要： The present invention relates to processes for preparing solid state forms of N-(4-(7-azabicyclo[2.2. 1]heptan-7-yl)-2-(trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide, including Compound 1 Form A, Compound 1 Form A- HCl, Compound 1 Form B, and Compound 1 Form B-HCl, any combination of these forms, pharmaceutical compositions thereof, and methods of treatment therewith.

4.

发明公开
PROCESS FOR PREPARING AZABICYCLIC COMPOUNDS 有权
标题翻译：用于生产的氮杂双环CONNECTIONS

公开(公告)号：EP2477991A1

公开(公告)日：2012-07-25

申请号：EP10757544.1

申请日：2010-09-17

申请人： Vertex Pharmaceuticals Incorporated

发明人： AMBHAIKAR, Narendra, Bhalchandra , BEAR, Brian, Richard , FANNING, Lev, T., D. , HUGHES, Robert , LITTLER, Benjamin

IPC分类号： C07D487/08

CPC分类号： C07D487/08

摘要： The present invention relates to a process for preparing azabicyclic compounds that are useful intermediates for synthesizing pharmaceutical compounds or salts thereof.