公开(公告)号：EP2219657A2

公开(公告)日：2010-08-25

申请号：EP08849380.4

申请日：2008-11-17

申请人： Biomedical Research Foundation of Northwest Louisiana ,  Louisiana State University ,  The UAB Research Foundation

发明人： KEVIL, Christopher ,  LEFER, David ,  PATEL, Rakesh

IPC分类号： A61K33/14 ,  A61K33/06 ,  A61P7/06

CPC分类号： A61K33/06 ,  A61K33/00 ,  A61K45/06

摘要： Methods of treating a subject who has chronic tissue ischemia are disclosed. The methods can include administering to the subject a pharmaceutical composition comprising inorganic nitrite or a pharmaceutically acceptable salt thereof, for a time and in an amount sufficient to result in blood vessel growth in the ischemic tissue. The subject can be diagnosed as having a medical condition that results in persistent or recurring restriction of blood supply to a tissue, for example, peripheral artery disease, diabetes, atherosclerotic cardiovascular disease or defective wound healing. The methods can include the step of identifying a suitable subject.

摘要翻译： 公开了治疗患有慢性组织缺血的受试者的方法。 所述方法可以包括向受试者施用包含无机亚硝酸盐或其药学上可接受的盐的药物组合物，其时间和量足以导致缺血组织中的血管生长。 该受试者可以被诊断为具有导致对组织的血液供应的持续或重复限制的医学病症，例如外周动脉疾病，糖尿病，动脉粥样硬化心血管疾病或有缺陷的伤口愈合。 所述方法可以包括鉴定合适的受试者的步骤。