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1.发明公开MONOCLONAL ANTIBODIES TO PROGASTRIN AND THEIR USES 有权MONVLONALEANTIKÖRPERGEGEN PROGASTRIN UND VERWENDUNGEN DAVON
公开(公告)号：EP2488551A2
公开(公告)日：2012-08-22
申请号：EP10768878.0
申请日：2010-10-15
申请人： Biorealites S.A.S. , Institut National de la Santé et de la Recherche Médicale (INSERM) , Centre National de la Recherche Scientifique CNRS
IPC分类号： C07K16/26
CPC分类号： C07K16/26 , A61K2039/505 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/57419 , G01N33/57488 , G01N2333/595
摘要： The present disclosure is directed to progastrin monoclonal antibodies, fragments thereof, compositions comprising progastrin monoclonal antibodies, and methods of making and using progastrin monoclonal antibodies and compositions thereof. The present disclosure is directed to methods of treating colorectal cancer with progastrin monoclonal antibodies and compositions comprising progastrin monoclonal antibodies or fragments thereof. The present disclosure is further directed to methods comprising detection of progastrin, including methods of diagnosing colorectal cancer and methods of monitoring efficacy of anti-cancer therapy in subjects suffering from colorectal cancer.
摘要翻译： 本公开涉及前列腺素单克隆抗体及其片段，包含前胃泌素单克隆抗体的组合物，以及制备和使用前列腺素单克隆抗体及其组合物的方法。 本公开涉及用前列腺素单克隆抗体治疗结肠直肠癌的方法和包含前列腺素单克隆抗体或其片段的组合物。 本公开进一步涉及包括检测前胃泌素的方法，包括诊断结肠直肠癌的方法和在患有结肠直肠癌的受试者中监测抗癌疗法的功效的方法。
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公开(公告)号：EP2542585B8
公开(公告)日：2017-12-13
申请号：EP11704178.0
申请日：2011-01-07
申请人： Progastrine et Cancers S.à r.l. , Institut National de la Santé et de la Recherche Médicale (INSERM) , Centre National de la Recherche Scientifique (CNRS)
发明人： PANNEQUIN, Julie , HOUHOU, Leïla , FRAMERY, Bérénice , ERKILIC, Nejla , JOUBERT, Dominique , HOLLANDE, Frédéric
IPC分类号： C07K16/26
CPC分类号： C07K16/26 , A61K39/39558 , A61K2039/505 , C07K5/1016 , C07K16/3046 , C07K2317/24 , C07K2317/73 , C07K2317/76 , G01N33/57419 , G01N2333/595 , G01N2800/52
摘要： The present disclosure is directed to methods of treating and preventing colorectal cancer metastasis or recurrence of colorectal cancer with compositions comprising anti-progastrin antibodies.
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公开(公告)号：EP2542585B1
公开(公告)日：2017-10-25
申请号：EP11704178.0
申请日：2011-01-07
申请人： Les Laboratoires Servier , Institut National de la Santé et de la Recherche Médicale (INSERM) , Centre National de la Recherche Scientifique (CNRS)
发明人： PANNEQUIN, Julie , HOUHOU, Leïla , FRAMERY, Bérénice , ERKILIC, Nejla , JOUBERT, Dominique , HOLLANDE, Frédéric
IPC分类号： C07K16/26
CPC分类号： C07K16/26 , A61K39/39558 , A61K2039/505 , C07K5/1016 , C07K16/3046 , C07K2317/24 , C07K2317/73 , C07K2317/76 , G01N33/57419 , G01N2333/595 , G01N2800/52
摘要： The present disclosure is directed to methods of treating and preventing colorectal cancer metastasis or recurrence of colorectal cancer with compositions comprising anti-progastrin antibodies.
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公开(公告)号：EP2488551B1
公开(公告)日：2018-07-25
申请号：EP10768878.0
申请日：2010-10-15
申请人： Progastrine et Cancers S.à r.l. , Institut National de la Santé et de la Recherche Médicale (INSERM) , Centre National de la Recherche Scientifique (C.N.R.S.)
IPC分类号： C07K16/26
CPC分类号： C07K16/26 , A61K2039/505 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/57419 , G01N33/57488 , G01N2333/595
摘要： The present disclosure is directed to progastrin monoclonal antibodies, fragments thereof, compositions comprising progastrin monoclonal antibodies, and methods of making and using progastrin monoclonal antibodies and compositions thereof. The present disclosure is directed to methods of treating colorectal cancer with progastrin monoclonal antibodies and compositions comprising progastrin monoclonal antibodies or fragments thereof. The present disclosure is further directed to methods comprising detection of progastrin, including methods of diagnosing colorectal cancer and methods of monitoring efficacy of anti-cancer therapy in subjects suffering from colorectal cancer.
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公开(公告)号：EP2542585A2
公开(公告)日：2013-01-09
申请号：EP11704178.0
申请日：2011-01-07
申请人： Bioréalités , INSERM - Institut National de la Santé et de la Recherche Médicale , Centre National de la Recherche Scientifique CNRS
发明人： PANNEQUIN, Julie , HOUHOU, Leïla , FRAMERY, Bérénice , ERKILIC, Nejla , JOUBERT, Dominique , HOLLANDE, Frédéric
IPC分类号： C07K16/26
CPC分类号： C07K16/26 , A61K39/39558 , A61K2039/505 , C07K5/1016 , C07K16/3046 , C07K2317/24 , C07K2317/73 , C07K2317/76 , G01N33/57419 , G01N2333/595 , G01N2800/52
摘要： The present disclosure is directed to methods of treating and preventing colorectal cancer metastasis or recurrence of colorectal cancer with compositions comprising anti-progastrin antibodies.
摘要翻译： 本公开涉及用包含抗前泌肽抗体的组合物治疗和预防结肠直肠癌转移或结肠直肠癌复发的方法。
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公开(公告)号：EP3296319A1
公开(公告)日：2018-03-21
申请号：EP17197865.3
申请日：2011-01-07
申请人： Centre National de la Recherche Scientifique (CNRS) , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , Progastrine et Cancers S.à r.l.
发明人： PANNEQUIN, Julie , HOUHOU, Leila , FRAMERY, Berenice , ERKILIC, Nejla , JOUBERT, Dominique , HOLLANDE, Frederic
IPC分类号： C07K16/26 , A61K39/395 , A61P35/00
CPC分类号： C07K16/26 , A61K39/39558 , A61K2039/505 , C07K5/1016 , C07K16/3046 , C07K2317/24 , C07K2317/73 , C07K2317/76 , G01N33/57419 , G01N2333/595 , G01N2800/52
摘要： The present disclosure is directed to methods of treating and preventing colorectal cancer metastasis or recurrence of colorectal cancer with compositions comprising anti-progastrin antibodies.
摘要翻译： 本公开涉及用包含抗前胃泌素抗体的组合物治疗和预防结肠直肠癌转移或结直肠癌复发的方法。
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公开(公告)号：EP3421493A1
公开(公告)日：2019-01-02
申请号：EP18185172.6
申请日：2010-10-15
申请人： Progastrine et Cancers S.à r.l. , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
IPC分类号： C07K16/26 , A61K39/395 , A61P35/00
摘要： The present disclosure is directed to progastrin monoclonal antibodies, fragments thereof, compositions comprising progastrin monoclonal antibodies, and methods of making and using progastrin monoclonal antibodies and compositions thereof. The present disclosure is directed to methods of treating colorectal cancer with progastrin monoclonal antibodies and compositions comprising progastrin monoclonal antibodies or fragments thereof. The present disclosure is further directed to methods comprising detection of progastrin, including methods of diagnosing colorectal cancer and methods of monitoring efficacy of anti-cancer therapy in subjects suffering from colorectal cancer.
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公开(公告)号：EP2040753A2
公开(公告)日：2009-04-01
申请号：EP07734620.3
申请日：2007-05-21
申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , Université de Montpellier I
发明人： HOLLANDE, Frédéric , JOUBERT, Dominique , JAY, Philippe , PANNEQUIN, Julie , DELAUNAY, Nathalie , BOURGAUX, Jean-François
CPC分类号： C07K16/26 , C07K2317/34 , C07K2317/76 , C12N15/1135 , C12N15/1136 , C12N2310/111 , C12N2310/14
摘要： The present invention relates to inhibitors of progastrin induced repression of ICAT for treating and/or preventing colorectal cancer, adenomatous polyposis or metastasis displaying progastrin-secreting cells and cells in which the beta-catenin/Tcf-4-mediated transcriptional pathway is constitutively active.
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公开(公告)号：EP2040753B8
公开(公告)日：2019-04-10
申请号：EP07734620.3
申请日：2007-05-21
申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE -CNRS- , Université de Montpellier
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公开(公告)号：EP2040753B1
公开(公告)日：2019-02-27
申请号：EP07734620.3
申请日：2007-05-21
申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE -CNRS- , Université de Montpellier
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