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公开(公告)号：EP2427216A2
公开(公告)日：2012-03-14
申请号：EP10718581.1
申请日：2010-05-05
申请人： Biotest AG , ImmunoGen, Inc.
发明人： OSTERROTH, Frank , UHEREK, Christoph , BRUECHER, Christoph , DAELKEN, Benjamin , ENGLING, André , HAEDER, Thomas , WARTENBERG-DEMAND, Andrea , NIEMANN, Gabriele , ZUBER, Chantal , CZELOTH, Niklas , AIGNER, Silke , ZENG, Steffen , SCHULZ, Gregor
CPC分类号： A61K47/6425 , A61K47/66 , A61K47/6851 , B82Y5/00
摘要： Disclosed are methods and treatment regimes that include the administration of immunconjugates targeting CD138 to combat diseases. The immunoconjugate is either used as the sole active ingredient, as part of a treatment regime or as part of an anticancer combination.
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公开(公告)号：EP2427216B1
公开(公告)日：2019-02-20
申请号：EP10718581.1
申请日：2010-05-05
申请人： Biotest AG , ImmunoGen, Inc.
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公开(公告)号：EP2470902B1
公开(公告)日：2017-07-19
申请号：EP10782326.2
申请日：2010-11-30
申请人： Biotest AG
发明人： OSTERROTH, Frank , UHEREK, Christoph , BRUECHER, Christoph , DAELKEN, Benjamin , ENGLING, André , ZUBER, Chantal , CZELOTH, Niklas , WALLMEIER, Holger , VÖLP, Kirsten , SCHULZ, Gregor
CPC分类号： G01N33/505 , C07K16/2812 , C07K2299/00 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/75 , G01N2333/70514
摘要： Provided are methods of screening to identify molecules capable of binding to CD4 and capable of activating CD4+CD25+ regulatory T cells. Further provided are antibodies and antibody fragments capable of activating CD4+CD25+ regulatory T cells and methods and uses involving the antibodies and fragments thereof.
摘要翻译： 提供筛选方法以鉴定能够结合CD4并能够激活CD4 + CD25 +调节性T细胞的分子。 还提供了能够激活CD4 + CD25 +调节性T细胞的抗体和抗体片段以及涉及该抗体及其片段的方法和用途。
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4.发明公开HUMANIZED ANTI-IL-10 ANTIBODIES FOR THE TREATMENT OF SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) 审中-公开人类抗IL-10抗体激动剂紫杉醇系统治疗红斑狼疮（SLE）
公开(公告)号：EP2470208A1
公开(公告)日：2012-07-04
申请号：EP10785417.6
申请日：2010-11-30
申请人： Biotest AG
发明人： OSTERROTH, Frank , UHEREK, Christoph , BRUECHER, Christoph , RÖTTGEN, Peter , DAELKEN, Benjamin , ENGLING, André , ZUBER, Chantal , CZELOTH, Niklas
IPC分类号： A61K39/395 , C07K16/24
CPC分类号： C07K16/244 , A61K2039/505 , C07K2299/00 , C07K2317/14 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/76 , C07K2317/92 , G01N33/6869
摘要： Provided is a humanized or chimeric antibody or fragment thereof capable of binding to interleukin-10 (IL-10), wherein said antibody or fragment thereof: (i) binds to the same region of IL-10 as the IL-10 receptor α(IL-I10Ra) and is not capable of binding IL-10 when the IL-10 is bound to the IL- 10 receptor; and (ii) binds to IL-10 in homodimeric form by binding a discontinuous epitope comprising residues of both monomers. Further provided are related products and methods involving the use of the antibody or fragment thereof.
摘要翻译： 提供能够结合白细胞介素-10（IL-10）的人源化或嵌合抗体或其片段，其中所述抗体或其片段：（i）结合与IL-10受体α相同的IL-10区域（ IL-10Ra），并且当IL-10与IL-10受体结合时不能结合IL-10; 和（ii）通过结合包含两个单体残基的不连续表位与同型二聚体形式的IL-10结合。 进一步提供涉及使用抗体或其片段的相关产物和方法。
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公开(公告)号：EP2470209B1
公开(公告)日：2020-01-01
申请号：EP10788050.2
申请日：2010-11-30
申请人： Biotest AG
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公开(公告)号：EP2470902A1
公开(公告)日：2012-07-04
申请号：EP10782326.2
申请日：2010-11-30
申请人： Biotest AG
发明人： OSTERROTH, Frank , UHEREK, Christoph , BRUECHER, Christoph , DAELKEN, Benjamin , ENGLING, André , ZUBER, Chantal , CZELOTH, Niklas , WALLMEIER, Holger , VÖLP, Kirsten , SCHULZ, Gregor
CPC分类号： G01N33/505 , C07K16/2812 , C07K2299/00 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/75 , G01N2333/70514
摘要： Provided are methods of screening to identify molecules capable of binding to CD4 and capable of activating CD4+CD25+ regulatory T cells. Further provided are antibodies and antibody fragments capable of activating CD4+CD25+ regulatory T cells and methods and uses involving the antibodies and fragments thereof.
摘要翻译： 提供了筛选以鉴定能够结合CD4并能够激活CD4 + CD25 +调节性T细胞的分子的方法。 还提供能够激活CD4 + CD25 +调节性T细胞的抗体和抗体片段以及涉及抗体及其片段的方法和用途。
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7.发明公开HUMANIZED ANTI-IL-10 ANTIBODIES FOR THE TREATMENT OF SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) 有权人源化抗IL-10抗体系统性红斑狼疮的治疗（SLE）
公开(公告)号：EP2470209A1
公开(公告)日：2012-07-04
申请号：EP10788050.2
申请日：2010-11-30
申请人： Biotest AG
发明人： OSTERROTH, Frank , UHEREK, Christoph , BRUECHER, Christoph , RÖTTGEN, Peter , DAELKEN, Benjamin , ENGLING, André , ZUBER, Chantal , CZELOTH, Niklas , WARTENBERG-DEMAND, Andrea , GUTSCHER, Marcus , WESSELS-KRANZ, Judith
IPC分类号： A61K39/395 , C07K16/24
摘要： Provided is a humanized or chimeric antibody or fragment thereof capable of binding to interleukin-10 (IL-10), wherein said antibody or fragment thereof: (i) binds to the same region of IL-10 as the IL-10 receptor α(IL-I10Ra) and is not capable of binding IL-10 when the IL-10 is bound to the IL- 10 receptor; and (ii) binds to IL-10 in homodimeric form by binding a discontinuous epitope comprising residues of both monomers. Further provided are related products and methods involving the use of the antibody or fragment thereof.
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