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1.发明公开Methods for Alzheimer's disease treatment and cognitive enhancement 有权Bryostatine zur Behandlung von Alzheimer-Krankheit und kognitiver Verbesserung
公开(公告)号：EP2172246A2
公开(公告)日：2010-04-07
申请号：EP10000734.3
申请日：2003-03-07
IPC分类号： A61P25/00 , A61P25/16 , A61P25/28 , A61K31/00 , A61K31/366
CPC分类号： A61K31/365 , A61K9/0053 , A61K31/00 , A61K31/366 , Y02A50/406
摘要： The present invention relates to compositions to modulate alpha-secretase and/or to improve cognitive ability. The invention further relates the improved/enhanced cognitive ability in diseased individuals, particularly Alzheimer's Disease patients, and treatment thereof through increased sAPP production. In the present invention PKC activators such as compounds of bryostatin or neristatin class are used for enhancing the cognitive ability.
摘要翻译： 本发明涉及调节α-分泌酶和/或改善认知能力的组合物。 本发明进一步涉及改善/增强的患病个体，特别是阿尔茨海默病患者的认知能力，以及通过增加的sAPP产生来治疗它们。 在本发明中，PKC活化剂如苔藓抑制素或神经抑制素类化合物用于增强认知能力。
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2.发明公开Methods for Alzheimer's disease treatment and cognitive enhancement 有权Verfahren zur Behandlung von Alzheimer und zur koginitiven Verbesserung
公开(公告)号：EP2172246A3
公开(公告)日：2010-05-05
申请号：EP10000734.3
申请日：2003-03-07
IPC分类号： A61P25/00 , A61P25/16 , A61P25/28 , A61K31/00 , A61K31/366
CPC分类号： A61K31/365 , A61K9/0053 , A61K31/00 , A61K31/366 , Y02A50/406
摘要： The present invention relates to compositions to modulate alpha-secretase and/or to improve cognitive ability. The invention further relates the improved/enhanced cognitive ability in diseased individuals, particularly Alzheimer's Disease patients, and treatment thereof through increased sAPP production. In the present invention PKC activators such as compounds of bryostatin or neristatin class are used for enhancing the cognitive ability.
摘要翻译： 本发明涉及调节α-分泌酶和/或改善认知能力的组合物。 本发明进一步涉及改善/增强的患病个体，特别是阿尔茨海默病患者的认知能力，以及通过增加的sAPP产生来治疗它们。 在本发明中，PKC活化剂如苔藓抑制素或神经抑制素类化合物用于增强认知能力。
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3.发明授权Bryostatins for the treatment of Alzheimer's disease and cognitive enhancement 有权Bryostatins用于治疗阿尔茨海默氏症和认知功能增强
公开(公告)号：EP2172246B1
公开(公告)日：2017-08-30
申请号：EP10000734.3
申请日：2003-03-07
IPC分类号： A61K31/366 , A61P25/00 , A61P25/16 , A61P25/28
CPC分类号： A61K31/365 , A61K9/0053 , A61K31/00 , A61K31/366 , Y02A50/406
摘要： The present invention relates to compositions to modulate alpha-secretase and/or to improve cognitive ability. The invention further relates the improved/enhanced cognitive ability in diseased individuals, particularly Alzheimer's Disease patients, and treatment thereof through increased sAPP production. In the present invention PKC activators such as compounds of bryostatin or neristatin class are used for enhancing the cognitive ability.
摘要翻译： 本发明涉及调节α-分泌酶和/或改善认知能力的组合物。 本发明进一步涉及患病个体特别是阿尔茨海默氏病患者的改善的/增强的认知能力，以及通过增加的sAPP产生对其进行治疗。 在本发明中，PKC活化剂如苔藓抑素或奈司他汀类化合物用于增强认知能力。
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