公开(公告)号：EP1546367A1

公开(公告)日：2005-06-29

申请号：EP03765999.2

申请日：2003-07-24

申请人： BOARD OF REGENTS THE UNIVERSITY OF TEXAS SYSTEM

发明人： MCDEVITT, John, T. ,  FLORIANO, Pierre ,  CHRISTODOULIDES, Nick, J. ,  GOODEY, Adrian ,  NEIKIRK, Dean ,  ANSLYN, Eric ,  SHEAR, Jason

IPC分类号： C12Q1/24 ,  C12M1/34

CPC分类号： G01N1/4077 ,  C12Q1/04 ,  C12Q1/22 ,  C12Q1/24 ,  G01N1/405 ,  G01N15/0227 ,  G01N15/0272 ,  G01N33/56911 ,  G01N2015/0088

摘要： Methods and systems for detecting the presence of analytes using a membrane based detection system are described. A fluid sample is passed through a membrane based detection system (100). Particulate analytes (e.g., microbes) are captured by the membrane (110). Detection and analysis techniques may be applied to determine the identity and quantity of the captured analytes.

公开(公告)号：EP1695082A2

公开(公告)日：2006-08-30

申请号：EP04813887.9

申请日：2004-12-13

申请人： Board of Regents, The University of Texas System

发明人： MCDEVITT, John, T. ,  ANSLYN, Eric, V. ,  SHEAR, Jason, B. ,  NEIKIRK, Dean, P. ,  CHRISTODOULIDES, Nick, J.

IPC分类号： G01N33/53 ,  G01N33/552 ,  G01N33/544 ,  G01N33/92 ,  B01L3/00

CPC分类号： G01N33/5304 ,  B01J19/0046 ,  B01J2219/00317 ,  B01J2219/005 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00702 ,  B01J2219/00725 ,  B01L3/5025 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/502738 ,  B01L3/502761 ,  B01L2300/0819 ,  B01L2300/0877 ,  B01L2400/0487 ,  C40B40/10 ,  C40B60/14 ,  G01N21/6428 ,  G01N21/6454 ,  G01N21/77 ,  G01N33/54313 ,  G01N33/544 ,  G01N33/552 ,  G01N33/6887 ,  G01N33/92 ,  G01N2021/7783 ,  G01N2021/7786 ,  G01N2201/024 ,  G01N2800/32 ,  Y10S436/807 ,  Y10S436/809

摘要： A system for the rapid characterization of analytes in saliva. In one embodiment, a system for detecting analytes includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member, in which a plurality of cavities may be formed. A series of chemically sensitive particles, in one embodiment, are positioned within the cavities. The particles may produce a signal when a receptor, coupled to the particle, interacts with the cardiovascular risk factor analyte and the particle-analyte complex is visualized using a visualization reagent. Using pattern recognition techniques, the analytes within a multi-analyte fluid may be characterized. In an embodiment, each cavity of the plurality of cavities is designed to capture and contain a specific size particle. Flexible projections may be positioned over each of the cavities to provide retention of the particles in the cavities.

公开(公告)号：EP1502097A2

公开(公告)日：2005-02-02

申请号：EP03726476.9

申请日：2003-04-28

申请人： Board of Regents,The University of Texas System

发明人： MCDEVITT, John, T. ,  ANSLYN, Eric, V. ,  SHEAR, Jason, B. ,  NEIKIRK, Dean, P. ,  CHRISTODOULIDES, Nick, J.

IPC分类号： G01N21/64 ,  G01N35/00 ,  B01J19/00

CPC分类号： G01N21/6452 ,  B01J2219/00286 ,  B01J2219/00353 ,  B01J2219/00389 ,  B01J2219/00414 ,  B01J2219/00416 ,  B01J2219/00423 ,  B01J2219/00454 ,  B01J2219/00468 ,  B01J2219/00497 ,  B01J2219/005 ,  B01J2219/00576 ,  B01J2219/00578 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00648 ,  B01J2219/00659 ,  B01J2219/00677 ,  B01J2219/00689 ,  B01J2219/00707 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00731 ,  B82Y30/00 ,  C40B40/06 ,  C40B40/10 ,  C40B40/12 ,  C40B50/14 ,  C40B60/14 ,  G01N21/6428 ,  G01N21/645 ,  G01N33/54313 ,  G01N33/54373 ,  G01N33/6893 ,  G01N35/0098 ,  G01N35/028 ,  G01N2001/021 ,  G01N2800/32

摘要： A system for the rapid characterization of multi-cardiovascular risk factor analyte fluids, in one embodiment, includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member, in which a plurality of cavities may be formed. A series of chemically sensitive particles, in one embodiment, are positioned within the cavities. The particles may produce a signal when a receptor, coupled to the particle, interacts with the cardiovascular risk factor analyte and the particle-analyte complex is visualized using a visualization reagent. Using pattern recognition techniques, the analytes within a multi-analyte fluid may be characterized. In an embodiment, each cavity of the plurality of cavities is designed to capture and contain a specific size particle. Flexible projections may be positioned over each of the cavities to provide retention of the particles in the cavities.

公开(公告)号：EP1735618A2

公开(公告)日：2006-12-27

申请号：EP05755340.6

申请日：2005-02-28

申请人： Board of Regents, The University of Texas System

发明人： MCDEVITT, John, T. ,  ANSLYN, Eric, V. ,  SHEAR, Jason, B. ,  NEIKIRK, Dean, P. ,  CHRISTODOULIDES, Nick, J. ,  MICHAEL-BALLARD, Karri, L. ,  FLORIANO, Pierre, N. ,  BERNARD, Bruce

IPC分类号： G01N33/543

CPC分类号： G01N21/25 ,  G01N21/64 ,  G01N33/52 ,  G01N33/543

摘要： Described herein is an analyte detection device and method related to a portable instrument suitable for point-of-care analyses. In some embodiments, a portable instrument may include a disposable cartridge, an optical detector, a sample collection device and/or sample reservoir, reagent delivery systems, fluid delivery systems, one or more channels, and/or waste reservoirs. Use of a portable instrument may reduce the hazard to an operator by reducing an operator's contact with a sample for analysis. The device is capable of obtaining diagnostic information using cellular- and/or particle-based analyses and may be used in conjunction with membrane- and/or particle-based analysis cartridges. Analytes, including proteins and cells and/or microbes may be detected using the membrane and/or particle based analysis system.

公开(公告)号：EP1723420A1

公开(公告)日：2006-11-22

申请号：EP05723785.1

申请日：2005-02-28

申请人： Board of Regents, The University of Texas System

发明人： MCDEVITT, John, T. ,  CHRISTODOULIDES, Nick, J. ,  FLORIANO, Pierre, N. ,  MICHAEL-BALLARD, Karri, L. ,  BERNARD, Bruce

IPC分类号： G01N33/543 ,  G01N33/50 ,  G01N21/25

CPC分类号： G01N21/6456 ,  C12Q1/6816 ,  G01N21/6452 ,  G01N21/6486 ,  G01N33/521 ,  G01N33/5302 ,  G01N2021/0321 ,  Y10S435/808 ,  Y10S436/80 ,  Y10S436/805

摘要： Described herein is an analyte detection device and method related to a portable instrument suitable for point-of-care analyses. In some embodiments, a portable instrument may include a disposable cartridge, an optical detector, a sample collection device and/or sample reservoir, reagent delivery systems, fluid delivery systems, one or more channels, and/or waste reservoirs. Use of a portable instrument may reduce the hazard to an operator by reducing an operator's contact with a sample for analysis. The device is capable of obtaining diagnostic information using cellular- and/or particle-based analyses and may be used in conjunction with membrane- and/or particle-based analysis cartridges. Analytes, including proteins and cells and/or microbes may be detected using the membrane and/or particle based analysis system.