专利检索 ap:("Boehringer Ingelheim Chemicals, Inc.") AND inv:"LO, Young, S.,Boehringer Ingelheim Chemicals, Inc" 第 1 页

1.

发明公开
PREPARATION OF AMPHETAMINES FROM PHENYLPROPANOLAMINES 有权
标题翻译：用于生产安非他明OFF PHENYLPROPANOLAMINEN

公开(公告)号：EP1442006A2

公开(公告)日：2004-08-04

申请号：EP02802245.7

申请日：2002-10-28

申请人： Boehringer Ingelheim Chemicals, Inc.

发明人： BOSWELL, Robert F.,Boehringer Ingelheim Chem. Inc , LO, Young, S.,Boehringer Ingelheim Chemicals, Inc

IPC分类号： C07C209/00

CPC分类号： C07C209/68 , C07C211/27

摘要： A process for making an amphetamine from a phenylpropanolamine salt, the process comprising: (a) acylating the phenylpropanolamine salt with an acylating agent in a solvent at elevated temperature to make a reaction mixture containing an O-acylated phenylpropanolamine salt which can be isolated by the addition of a crystallization solvent, or optionally this mixture can be used in the next step; and (b) hydrogenating the O-acylated phenylpropanolamine salt to make the amphetamine in thepresence of a catalyst.