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1.发明公开NEW AZABENZIMIDAZOLE DERIVATIVES AS AGONISTS OF THE AMP-ACTIVATED PROTEIN KINASE 审中-公开作为AMP激活的蛋白激酶的激动剂的新的氮杂苯并咪唑衍生物
公开(公告)号：EP3245210A1
公开(公告)日：2017-11-22
申请号：EP16700807.7
申请日：2016-01-13
IPC分类号： C07D493/04 , A61K31/437 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/12
CPC分类号： A61K31/4188 , A61K31/34 , A61K31/437 , C07D493/04 , C12N9/12
摘要： The present invention relates to compounds of general formula I, wherein the group R1, X and Y are defined as in claim 1, which have valuable pharmacological properties, in particular bind to the AMP-activated protein kinase (AMPK) and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2.
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2.发明公开
公开(公告)号：EP3455216A1
公开(公告)日：2019-03-20
申请号：EP17721706.4
申请日：2017-05-08
IPC分类号： C07D401/14 , C07D405/14 , C07D413/14 , C07D401/04 , C07D417/14 , A61K31/506 , A61P1/16
摘要： wherein R1 and A are as defined in the description and claims, to their use as medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them.
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公开(公告)号：EP3455216B1
公开(公告)日：2020-11-04
申请号：EP17721706.4
申请日：2017-05-08
IPC分类号： C07D401/14 , C07D405/14 , C07D413/14 , C07D401/04 , C07D417/14 , A61K31/506 , A61P1/16
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公开(公告)号：EP4045144A1
公开(公告)日：2022-08-24
申请号：EP20789985.7
申请日：2020-10-14
发明人： FLECK, Martin, Thomas , BINDER, Florian, Paul, Christian , DAHMANN, Georg , HEHN, Joerg, P. , HEIMANN, Annekatrin, Charlotte , LESSEL, Uta, Friederike , WILLWACHER, Jens
IPC分类号： A61P11/00 , C07D495/04 , C07D495/14 , A61K31/519
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公开(公告)号：EP4045053A1
公开(公告)日：2022-08-24
申请号：EP20793302.9
申请日：2020-10-14
发明人： FLECK, Martin, Thomas , BINDER, Florian, Paul, Christian , DAHMANN, Georg , HEHN, Joerg, P. , LESSEL, Uta, Friederike , WILLWACHER, Jens
IPC分类号： A61K31/522 , A61K31/53 , A61P13/00 , A61P17/00 , A61P29/00
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公开(公告)号：EP3612523A1
公开(公告)日：2020-02-26
申请号：EP18719794.2
申请日：2018-04-16
发明人： FRATTINI, Sara , LINGARD, Iain , HAMPRECHT, Dieter, Wolfgang , BAKKER, Remko, Alexander , ECKHARDT, Matthias , GOLLNER, Andreas , HEHN, Joerg, P. , LANGKOPF, Elke , WAGNER, Holger , WELLENZOHN, Bernd , WIEDENMAYER, Dieter
IPC分类号： C07D401/14 , A61P3/10 , A61K31/444 , A61K31/506
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公开(公告)号：EP4045509A1
公开(公告)日：2022-08-24
申请号：EP20790303.0
申请日：2020-10-14
发明人： FLECK, Martin, Thomas , BINDER, Florian, Paul, Christian , DAHMANN, Georg , HEHN, Joerg, P. , HEIMANN, Annekatrin, Charlotte , WILLWACHER, Jens
IPC分类号： C07D495/04 , C07D495/14 , A61P11/00 , A61K31/519
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公开(公告)号：EP3245210B1
公开(公告)日：2018-10-24
申请号：EP16700807.7
申请日：2016-01-13
IPC分类号： C07D493/04 , A61K31/437 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/12
CPC分类号： A61K31/4188 , A61K31/34 , A61K31/437 , C07D493/04 , C12N9/12
摘要： The present invention relates to compounds of general formula I, wherein the group R1, X and Y are defined as in claim 1, which have valuable pharmacological properties, in particular bind to the AMP-activated protein kinase (AMPK) and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2.
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