公开(公告)号：EP2655349B1

公开(公告)日：2014-10-15

申请号：EP11810721.8

申请日：2011-12-15

申请人： Boehringer Ingelheim International GmbH

发明人： FANDRICK, Daniel Robert ,  LU, Zhi-Hui ,  REEVES, Diane Crimhilda ,  REEVES, Jonathan Timothy ,  SENANAYAKE, Chris Hugh ,  SONG, Jinhua J. ,  ZHANG, Yongda

IPC分类号： C07D265/10 ,  C07C271/16

CPC分类号： C07D413/10 ,  C07C271/48 ,  C07D213/64 ,  C07D265/10

公开(公告)号：EP2655349A1

公开(公告)日：2013-10-30

申请号：EP11810721.8

申请日：2011-12-15

申请人： Boehringer Ingelheim International GmbH

发明人： FANDRICK, Daniel Robert ,  LU, Zhi-Hui ,  REEVES, Diane Crimhilda ,  REEVES, Jonathan Timothy ,  SENANAYAKE, Chris Hugh ,  SONG, Jinhua J. ,  ZHANG, Yongda

IPC分类号： C07D265/10 ,  C07C271/16

CPC分类号： C07D413/10 ,  C07C271/48 ,  C07D213/64 ,  C07D265/10

摘要： Disclosed is a process for making diastereomeric compound of the formula (I): wherein m, n and R
1 to R
4 are as defined herein. The process of the invention provides the compound of formula (I) in high yield and substantially free of the corresponding diastereomers. The compounds of formula (I) prepared by the process of the invention are useful for making pharmaceutically active compounds such as 11- β-hydroxysteroid hydrogenase type 1 (11- β-HSD1) inhibitors.