公开(公告)号：EP1668132A1

公开(公告)日：2006-06-14

申请号：EP04764749.0

申请日：2004-09-02

申请人： Boehringer Ingelheim International GmbH

发明人： WAERNER, Thomas ,  BEUG, Hartmut ,  JECHLINGER, Martin ,  GRUENERT, Stefan ,  TAMIR, Ido ,  KRAUT, Norbert ,  HEIDER, Karl-Heinz ,  SEITHER, Peter ,  WEITH, Andreas ,  ZOEPHEL, Andreas ,  KONOPITZKY, Renate ,  AHORN, Horst ,  JUNG, Birgit

IPC分类号： C12N15/19 ,  C07K14/52 ,  C12N15/11 ,  C07K16/24 ,  A61K31/70 ,  A61K39/395 ,  A61P17/02 ,  A61P35/00 ,  A61P35/04

CPC分类号： C12N15/1136 ,  A61K38/00 ,  C07K14/52

摘要： The functional characterization of ILEI to be a cytokine involved in epithelial/mesenchymal transition and the identification of biologically active ILEI provides the basis for generating ILEI inhibitors, in particular anti-ILEI antibodies, that are useful in the therapy of cancer, fibrosis and COPD.