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1.发明公开CRYSTALLINE FORM OF 1´-(1-METHYLETHYL)- 4´-[(2-FLUORO-4-METHOXYPHENYL)METHYL]-5´-METHYL-1H-PYRAZOL-3´-O-beta-D-GLUCOPYRANOSIDE, A METHOD FOR ITS PREPARATION AND THE USE THEREOF FOR PREPARING MEDICAMENTS 审中-公开4' - [（2-氟-4-甲氧基苯基）甲基] -5'-甲基-1H-吡唑-3'-O-BETA-D-吡喃葡糖苷，METHODS - 的1,1'-（1-甲基乙基）结晶形式 其制备和它们在药品生产
公开(公告)号：EP1976859A1
公开(公告)日：2008-10-08
申请号：EP07703756.2
申请日：2007-01-10
申请人： Boehringer Ingelheim International GmbH , Ajinomoto Co., Inc. , Boehringer Ingelheim Pharma GmbH & Co. KG
发明人： KRAEMER, Gerd , MARTIN, Hans-Jürgen , ADELGOSS, Gebhard , DUGI, Klaus , DURAN, Adil , EICKELMANN, Peter , MAIER, Steffen , PINNETTI, Sabine , RITTER, Regine , SCHILCHER, Gebhard , STREICHER, Ruediger , THOMAS, Leo
IPC分类号： C07H17/02 , A61K31/7056 , A61P3/10
CPC分类号： C07H17/02
摘要： The invention relates to a crystalline form of 1´-(1-methylethyl)- 4´-[(2-fluoro-4- methoxyphenyl)methyl]-5´-methyl-1H-pyrazol-3´-O-β-D-glucopyranoside, to a method for the preparation thereof, as well as to the use thereof for preparing medicaments.
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2.发明公开METHODS FOR PREVENTING AND TREATING METABOLIC DISORDERS AND NEW PYRAZOLE-O-GLYCOSIDE DERIVATIVES 审中-公开FOR预防方法和代谢性疾病和新吡-O-糖苷衍生物的治疗
公开(公告)号：EP1912656A2
公开(公告)日：2008-04-23
申请号：EP06778010.6
申请日：2006-07-27
发明人： HIMMELSBACH, Frank , MAIER, Roland , EICKELMANN, Peter , THOMAS, Leo , BARSOUMIAN, Edward, Leon , DUGI, Klaus , PINNETTI, Sabine , RITTER, Regine , STREICHER, Ruediger , FUJITA, Koichi , HATANAKA, Toshihiro , ISHIDA, Nozomu , MAEZONO, Katsumi , OHSUMI, Koji
IPC分类号： A61K31/7056 , C07H17/02 , A61P3/04 , A61P3/10
CPC分类号： A61K31/7056 , C07H17/02
摘要： The invention relates to methods for preventing or treating metabolic disorders, for improving glycemic control, for preventing progression from impaired glucose tolerance, insulin resistance and/or from metabolic syndrome to type 2 diabetes mellitus, for preventing or treating of complications of diabetes mellitus, for reducing the weight, for preventing or treating the degeneration of pancreatic beta cells, for treating hyperinsulinemia and insulin resistance and diabetes type 1, in patients in need thereof by administering a pharmaceutical composition comprising a pyrazole-O-glycoside as defined in claim 1 , or a prodrug thereof, or a pharmaceutically acceptable salt thereof.
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3.发明公开PHARMACEUTICAL COMPOSITION COMPRISING A PYRAZOLE-O-GLUCOSIDE DERIVATIVE 审中-公开WITH A - 吡唑O-葡萄糖苷衍生物的药物组合物
公开(公告)号：EP2124970A1
公开(公告)日：2009-12-02
申请号：EP08707978.6
申请日：2008-01-18
CPC分类号： A61K45/06 , A61K9/0019 , A61K9/0031 , A61K9/02 , A61K9/145 , A61K9/1623 , A61K9/2018 , A61K9/2072 , A61K9/4858 , A61K31/7056 , A61K2300/00
摘要： The invention relates toa pharmaceutical composition comprising a pyrazole-O-glucoside derivative selected from the group of compounds (1) to (29) according to claim 1 in combination with at least one second therapeutic agent which is suitable in the treatment or prevention of one or more conditions selected from type 1 diabetes mellitus, type 2 diabetes mellitus, impaired glucose tolerance and hyperglycemia. In addition the present invention relates to methods for preventing or treating of metabolic disorders and related conditions.
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