公开(公告)号：EP2155748A1

公开(公告)日：2010-02-24

申请号：EP08769442.8

申请日：2008-05-12

申请人： Boehringer Ingelheim International GmbH ,  Boehringer Ingelheim Pharma GmbH & Co. KG

发明人： COOK, Brian Nicholas ,  ELDRUP, Anne Bettina ,  MUGGE, Ingo Andreas ,  SOLEYMANZADEH, Fariba ,  SUN, Sanxing ,  ZHANG, Yunlong

IPC分类号： C07D471/04 ,  A61K31/4375 ,  A61P9/12

CPC分类号： C07D471/04

摘要： Compounds of the formula (I) wherein R1, R2, R3, R4, R5, R6, W, and Y are as described herein, or a tautomer, prodrug, solvate, or salt thereof. These compounds are useful as inhibitors of Urotensin II and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the interaction of Urotensin II with its receptor, including cardiovascular diseases. This invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds, and intermediates useful in these processes.