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公开(公告)号：EP2285783B1
公开(公告)日：2014-05-21
申请号：EP09739468.8
申请日：2009-04-23
发明人： DISALVO, Darren , KUZMICH, Daniel , MAO, Can , RAZAVI, Hossein , SARKO, Christopher , SWINAMER, Alan, David , THOMSON, David , ZHANG, Qiang
IPC分类号： C07D231/56 , C07D401/12 , A61K31/416 , A61P19/02 , A61P25/28
CPC分类号： C07D231/56 , C07D401/12
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公开(公告)号：EP2285783A1
公开(公告)日：2011-02-23
申请号：EP09739468.8
申请日：2009-04-23
发明人： DISALVO, Darren , KUZMICH, Daniel , MAO, Can , RAZAVI, Hossein , SARKO, Christopher , SWINAMER, Alan, David , THOMSON, David , ZHANG, Qiang
IPC分类号： C07D231/56 , C07D401/12 , A61K31/416 , A61P19/02 , A61P25/28
CPC分类号： C07D231/56 , C07D401/12
摘要： Disclosed indazoles compounds that are useful as antagonists of CCR1 activity and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Also disclosed are pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
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