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1.发明公开NEW PYRIDAZINE DERIVATIVES WITH MCH ANTAGONISTIC ACTIVITY AND MEDICAMENTS COMPRISING THESE COMPOUNDS 审中-公开与MCH拮抗作用及药物的新哒嗪，该链接包
公开(公告)号：EP2102171A1
公开(公告)日：2009-09-23
申请号：EP07848015.9
申请日：2007-12-10
发明人： LEHMANN-LINTZ, Thorsten , STENKAMP, Dirk , ROTH, Gerald Juergen , MUELLER, Stephan Georg , KLEY, Joerg , HECKEL, Armin , RUDOLF, Klaus , SCHINDLER, Marcus , LOTZ, Ralf , TIELMANN, Patrick
IPC分类号： C07D237/14 , C07D401/06 , C07D401/10 , C07D403/06 , C07D403/10 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/06 , C07D409/12 , C07D409/14 , C07D417/10 , C07D471/04 , A61K31/50 , A61K31/501 , A61P3/04
CPC分类号： C07D237/14 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/06 , C07D403/10 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/06 , C07D409/12 , C07D409/14 , C07D417/10 , C07D471/04
摘要： The present invention relates to compounds of general formula I wherein the groups and radicals B, W, X, Y, Z, R1, R2, have the meanings given in claim 1. Moreover the invention relates to pharmaceutical compositions containing at least one compound according to the invention. By virtue of their MCH-receptor antagonistic activity the pharmaceutical compositions according to the invention are suitable for the treatment of metabolic disorders and/or eating disorders, particularly obesity, bulimia, anorexia, hyperphagia and diabetes.
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2.发明授权CYCLIC PYRIMIDIN-4-CARBOXAMIDES AS CCR2 RECEPTOR ANTAGONISTS FOR TREATMENT OF INFLAMMATION, ASTHMA AND COPD 有权CYCLIC嘧啶-4-羧酸酰胺AS CCR2受体为炎症，哮喘和COPD于治疗拮抗剂
公开(公告)号：EP2379525B1
公开(公告)日：2015-07-29
申请号：EP09775212.5
申请日：2009-12-17
发明人： EBEL, Heiner , FRATTINI, Sara , GIOVANNINI, Riccardo , HOENKE, Christoph , TRIESELMANN, Thomas , TIELMANN, Patrick , SCHEUERER, Stefan , HOBBIE, Silke (Marie Katrin) , BUETTNER, Frank
IPC分类号： C07D405/14 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K31/553 , C07D417/14 , C07D451/02 , C07D471/04 , C07D491/052 , C07D498/10 , C07D401/14 , C07D413/14 , A61K31/506 , C07D401/06 , C07D403/06 , C07D403/14 , C07D407/14 , C07D471/10
CPC分类号： C07D498/10 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K31/553 , C07D401/06 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14 , C07D407/14 , C07D413/14 , C07D417/14 , C07D451/02 , C07D471/04 , C07D471/10 , C07D491/052 , Y02A50/385 , Y02A50/409 , Y02A50/411
摘要： The present invention relates to a process for the production of novel antagonists for CCR2 (CC chemokine receptor 2) of formula (I) from 6-Chloro-pyrimidine-methanone intermediates. Formula (I): Specifically claimed 6-chloropyrimidine-methanone intermediates are:
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3.发明公开CYCLIC PYRIMIDIN-4-CARBOXAMIDES AS CCR2 RECEPTOR ANTAGONISTS FOR TREATMENT OF INFLAMMATION, ASTHMA AND COPD 有权CYCLIC嘧啶-4-羧酸酰胺AS CCR2受体为炎症，哮喘和COPD于治疗拮抗剂
公开(公告)号：EP2379525A1
公开(公告)日：2011-10-26
申请号：EP09775212.5
申请日：2009-12-17
发明人： EBEL, Heiner , FRATTINI, Sara , GIOVANNINI, Riccardo , HOENKE, Christoph , TRIESELMANN, Thomas , TIELMANN, Patrick , SCHEUERER, Stefan , HOBBIE, Silke (Marie Katrin) , BUETTNER, Frank
IPC分类号： C07D401/06 , C07D401/14 , C07D403/06 , C07D413/14 , A61K31/506 , A61P29/00 , C07D407/14 , C07D471/10
CPC分类号： C07D498/10 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K31/553 , C07D401/06 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14 , C07D407/14 , C07D413/14 , C07D417/14 , C07D451/02 , C07D471/04 , C07D471/10 , C07D491/052 , Y02A50/385 , Y02A50/409 , Y02A50/411
摘要： The present invention relates to a process for the production of novel antagonists for CCR2 (CC chemokine receptor 2) of formula (I) from 6-Chloro-pyrimidine-methanone intermediates. Formula (I): Specifically claimed 6-chloropyrimidine-methanone intermediates are:
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