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1.发明公开NEUE ALKYL-HALTIGE 5-ACYLINDOLINONE, DEREN HERSTELLUNG UND DEREN VERWENDUNG ALS ARZNEIMITTEL 有权新的含烷基5 ACYLINDOLINONE，其制备及其作为药物
公开(公告)号：EP1727799A1
公开(公告)日：2006-12-06
申请号：EP05715811.5
申请日：2005-03-05
发明人： HECKEL, Armin , ROTH, Gerald Jürgen , KLEY, Jörg , HOERER, Stefan , UPHUES, Ingo
IPC分类号： C07D209/34 , C07D401/12 , C07D405/06 , C07D405/14 , C07D403/06 , C07D401/06 , A61K31/501 , A61P25/28
CPC分类号： C07D401/06 , C07D209/34 , C07D401/12 , C07D403/06 , C07D405/06 , C07D405/14
摘要： The invention relates to alkyl-containing 5-acylindolinones of the general formula (I), where R1 to R3 are as defined in claim 1, and to tautomers, enantiomers, diastereomers, mixtures and salts thereof with valuable pharmacological properties, more particularly an inhibitory effect on protein kinases, more particularly an inhibitory effect on the activity of glycogen synthase kinase (GSK-3).
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2.发明公开NEUE CYCLOALKYL-HALTIGE 5-ACYLINDOLINONE, DEREN HERSTELLUNG UND DEREN VERWENDUNG ALS ARZNEIMITTEL 有权NEW环烷基含有5-ACYLINDOLINONE，其制备及其作为药物
公开(公告)号：EP1727812A1
公开(公告)日：2006-12-06
申请号：EP05715812.3
申请日：2005-03-05
发明人： HECKEL, Armin , ROTH, Gerald Jürgen , KLEY, Jörg , HOERER, Stefan , UPHUES, Ingo
IPC分类号： C07D401/14 , C07D403/06 , C07D405/06 , C07D405/14 , C07D401/12 , C07D209/34 , C07D451/14 , C07D403/12 , C07D409/14
CPC分类号： C07D209/34 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/06 , C07D405/14 , C07D409/14 , C07D451/14
摘要： The invention relates to cycloalkyl-containing 5-acylindolinones of the general formula (I), where R1 to R3 are as defined in claims 1 to 6, and to tautomers, enantiomers, diastereomers, mixtures and salts thereof with valuable pharmacological properties, more particularly an inhibitory effect on protein kinases, more particularly an inhibitory effect on the activity of glycogen synthase kinase (GSK-3).
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3.发明授权NEUE ALKYL-HALTIGE 5-ACYLINDOLINONE, DEREN HERSTELLUNG UND DEREN VERWENDUNG ALS ARZNEIMITTEL 有权新的含烷基5 ACYLINDOLINONE，其制备及其作为药物
公开(公告)号：EP1727799B1
公开(公告)日：2009-01-07
申请号：EP05715811.5
申请日：2005-03-05
发明人： HECKEL, Armin , ROTH, Gerald Jürgen , KLEY, Jörg , HOERER, Stefan , UPHUES, Ingo
IPC分类号： C07D209/34 , C07D401/12 , C07D405/06 , C07D405/14 , C07D403/06 , C07D401/06 , A61K31/501 , A61P25/28
CPC分类号： C07D401/06 , C07D209/34 , C07D401/12 , C07D403/06 , C07D405/06 , C07D405/14
摘要： The invention relates to alkyl-containing 5-acylindolinones of the general formula (I), where R1 to R3 are as defined in claim 1, and to tautomers, enantiomers, diastereomers, mixtures and salts thereof with valuable pharmacological properties, more particularly an inhibitory effect on protein kinases, more particularly an inhibitory effect on the activity of glycogen synthase kinase (GSK-3).
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4.发明授权NEUE ARYL-HALTIGE 5-ACYLINDOLINONE, DEREN HERSTELLUNG UND DEREN VERWENDUNG ALS ARZNEIMITTEL 有权NEY ARYL-HALTIGE 5-ACYLINDOLINONE，DEREN HERSTELLUNG UND DEREN VERWENDUNG ALS ARZNEIMITTEL
公开(公告)号：EP1727798B1
公开(公告)日：2008-10-29
申请号：EP05715810.7
申请日：2005-03-05
IPC分类号： C07D209/34 , A61K31/404
CPC分类号： C07D209/34 , C07D403/12 , C07D405/06
摘要： The invention relates to aryl-containing 5-acylindolinones of general formula (I) in which R1 to R3 are defined as in Claims 1 to 7, the tautomers, enantiomers, diastereomers, mixtures and salts thereof, all of which having valuable pharmacological properties, particularly an inhibitory effect upon protein kinases, particularly an inhibitory effect upon the activity of glycogen synthase kinase (GSK-3).
摘要翻译： 本发明涉及通式为其中R 1至R 3的芳基的5-取代吲哚酮，其互变异构体，对映异构体，非对映异构体，其混合物 其具有有价值的药理学特性，特别是对蛋白激酶的抑制作用，特别是对糖原合酶激酶（GSK-3）的活性的抑制作用。
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5.发明授权NEUE CYCLOALKYL-HALTIGE 5-ACYLINDOLINONE, DEREN HERSTELLUNG UND DEREN VERWENDUNG ALS ARZNEIMITTEL 有权NEW环烷基含有5-ACYLINDOLINONE，其制备及其作为药物
公开(公告)号：EP1727812B1
公开(公告)日：2008-12-31
申请号：EP05715812.3
申请日：2005-03-05
发明人： HECKEL, Armin , ROTH, Gerald Jürgen , KLEY, Jörg , HOERER, Stefan , UPHUES, Ingo
IPC分类号： C07D401/14 , C07D403/06 , C07D405/06 , C07D405/14 , C07D401/12 , C07D209/34 , C07D451/14 , C07D403/12 , C07D409/14
CPC分类号： C07D209/34 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/06 , C07D405/14 , C07D409/14 , C07D451/14
摘要： The invention relates to cycloalkyl-containing 5-acylindolinones of the general formula (I), where R1 to R3 are as defined in claims 1 to 6, and to tautomers, enantiomers, diastereomers, mixtures and salts thereof with valuable pharmacological properties, more particularly an inhibitory effect on protein kinases, more particularly an inhibitory effect on the activity of glycogen synthase kinase (GSK-3).
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6.发明公开NEUE ARYL-HALTIGE 5-ACYLINDOLINONE, DEREN HERSTELLUNG UND DEREN VERWENDUNG ALS ARZNEIMITTEL 有权新芳基含5-ACYLINDOLINONE，其制备及其作为药物
公开(公告)号：EP1727798A1
公开(公告)日：2006-12-06
申请号：EP05715810.7
申请日：2005-03-05
IPC分类号： C07D209/34 , A61K31/404
CPC分类号： C07D209/34 , C07D403/12 , C07D405/06
摘要： The invention relates to aryl-containing 5-acylindolinones of general formula (I) in which R1 to R3 are defined as in Claims 1 to 7, the tautomers, enantiomers, diastereomers, mixtures and salts thereof, all of which having valuable pharmacological properties, particularly an inhibitory effect upon protein kinases, particularly an inhibitory effect upon the activity of glycogen synthase kinase (GSK-3).
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