-
公开(公告)号：EP2111237A2
公开(公告)日：2009-10-28
申请号：EP07862810.4
申请日：2007-12-11
发明人： BUSSAT, Philippe , LAMY, Bernard , MARINELLI, Edmund R. , POCHON, Sibylle , SONG, Bo , SWENSON, Rolf E.
CPC分类号： A61K49/14 , A61K49/0043 , A61K49/0056 , A61K49/085 , A61K49/124 , C07K7/06 , G01N33/532 , G01N33/574 , G01N33/86 , G01N2500/04
摘要： Fibrin-binding peptides having high binding affinity and excellent physical characteristics compared to previously known fibrin-binding peptides are provided. These fibrin-binding peptides may be conjugated to a detectable label or a therapeutic agent and used to detect and facilitate treatment of pathological conditions associated with the presence of fibrin such as thrombic, angiogenic and neoplastic conditions. These peptides may be used in imaging processes such as MRI, ultrasound and nuclear medicine imaging (e.g. PET, scintigraphic imaging., etc.). The peptides may also be used therapeutically. The present invention also provides processes and methods for making and using such peptides and conjugates thereof.
-
2.发明授权FIBRIN BINDING PEPTIDE CONJUGATES FOR DIAGNOSTIC AND THERAPEUTIC APPLICATIONS 有权FIBRINBINDENDE肽偶联物用于诊断和治疗应用
公开(公告)号：EP2097438B1
公开(公告)日：2015-08-26
申请号：EP07848047.2
申请日：2007-12-11
申请人： Bracco Imaging S.p.A
发明人： MARINELLI, Edmund , RAMALINGAM, Kondareddiar , SWENSON, Rolf , SONG, Bo , LATTUADA, Luciano , UGGERI, Fulvio , LORUSSO, Vito , AIME, Silvio , MOROSINI, Pierfrancesco , CHAABANE, Linda
CPC分类号： A61K49/14 , A61K49/0043 , A61K49/0056 , A61K49/085 , A61K49/124 , C07K7/06 , G01N33/532 , G01N33/574 , G01N33/86 , G01N2500/04
-
公开(公告)号：EP2111237B1
公开(公告)日：2015-03-18
申请号：EP07862810.4
申请日：2007-12-11
发明人： BUSSAT, Philippe , LAMY, Bernard , MARINELLI, Edmund R. , POCHON, Sibylle , SONG, Bo , SWENSON, Rolf E.
CPC分类号： A61K49/14 , A61K49/0043 , A61K49/0056 , A61K49/085 , A61K49/124 , C07K7/06 , G01N33/532 , G01N33/574 , G01N33/86 , G01N2500/04
-
4.发明公开FIBRIN BINDING PEPTIDE CONJUGATES FOR DIAGNOSTIC AND THERAPEUTIC APPLICATIONS. 有权FIBRINBINDENDE肽偶联物用于诊断和治疗应用
公开(公告)号：EP2097438A1
公开(公告)日：2009-09-09
申请号：EP07848047.2
申请日：2007-12-11
申请人： Bracco Imaging S.p.A
发明人： MARINELLI, Edmund , RAMALINGAM, Kondareddiar , SWENSON, Rolf , SONG, Bo , LATTUADA, Luciano , UGGERI, Fulvio , LORUSSO, Vito , AIME, Silvio , MOROSINI, Pierfrancesco , CHAABANE, Linda
CPC分类号： A61K49/14 , A61K49/0043 , A61K49/0056 , A61K49/085 , A61K49/124 , C07K7/06 , G01N33/532 , G01N33/574 , G01N33/86 , G01N2500/04
摘要： The present invention relates to a novel class of diagnostically or therapeutically effective compounds comprising novel peptides able to bind fibrin, to a process for their preparation and to compositions thereof for use in therapy and diagnostics. The compounds of the invention bind, in particular, to fibrin present in the extracellular matrix (EC) of tumor or connective tissue of stroma thus acting as targeting moieties able to bring and successfully bound an active moiety linked thereto to fibrin depositions inside solid tumors.
-
-
-
搜索结果
4 条记录 (耗时 0.024 秒)
