公开(公告)号：EP1753708B1

公开(公告)日：2018-02-21

申请号：EP05711939.8

申请日：2005-01-19

申请人： Brigham Young University

发明人： ANDRUS, Merritt, B. ,  LIU, Jing

IPC分类号： C07C67/08 ,  C07C67/14 ,  C07C67/287 ,  C07C67/29 ,  C07C67/293 ,  C07C69/017 ,  C07C69/16 ,  C07C69/18 ,  C07C69/63 ,  C07C69/716

CPC分类号： C07C69/017 ,  C07C67/08 ,  C07C67/14 ,  C07C67/287 ,  C07C67/29 ,  C07C67/293 ,  Y02P20/55 ,  C07C69/716 ,  C07C69/63 ,  C07C69/18 ,  C07C69/16

摘要： The present invention includes methods for preparing resveratrol, resveratrol esters and substituted and unsubstituted stilbenes of the formula given below; where each Y is —O or halogen, each Z is —O or halogen, each n and each m is independently the value of 0, 1, 2, 3, 4 or 5, each A and each B is independently selected from Pn, R or absent, each V and each W is independently selected from Pn, straight or branched alkyl of from 2 to 6 carbon atoms and cycloalkyl of from 3 to 8 carbon atoms, alkoxy, phenyl, benzyl or halogen, R is independently selected from the group comprising alkyl with at least one carbon atom, aryl and aralkyl, Pn is an alcohol protecting group and diastereoisomers of the foregoing. The compounds are made from a multi-step process including a N-heterocyclic carbene-type ligand coupling in the presence of a base with benzyol halide and styrene coupling partners. These compounds show increased stability for use in the food, cosmetic and pharmaceutical industries.

公开(公告)号：EP1753708A2

公开(公告)日：2007-02-21

申请号：EP05711939.8

申请日：2005-01-19

申请人： Brigham Young University

发明人： ANDRUS, Merritt, B. ,  LIU, Jing

IPC分类号： C07C39/215 ,  C07C69/017

CPC分类号： C07C69/017 ,  C07C67/08 ,  C07C67/14 ,  C07C67/287 ,  C07C67/29 ,  C07C67/293 ,  Y02P20/55 ,  C07C69/716 ,  C07C69/63 ,  C07C69/18 ,  C07C69/16

摘要： The present invention includes methods for preparing resveratrol, resveratrol esters and substituted and unsubstituted stilbenes of the formula given below; where each Y is -O or halogen, each Z is -O or halogen, each n and each m is independently the value of 0, 1, 2, 3, 4 or 5, each A and each B is independently selected from Pn, R or absent, each V and each W is independently selected from Pn, straight or branched alkyl of from (2) to (6) carbon atoms and cycloalkyl of from (3) to (8) carbon atoms, alkoxy, phenyl, benzyl or halogen, R is independently selected from the group comprising alkyl with at least one carbon atom, aryl and aralkyl, Pn is an alcohol protecting group and diastereoisomers of the foregoing. The compounds are made from a multi-step process including a N-heterocyclic carbene-type ligand coupling in the presence of a base with benzyol halide and styrene coupling partners. These compounds show increased stability for use in the food, cosmetic and pharmaceutical industries.

摘要翻译： 本发明包括用于制备下式给出的白藜芦醇，白藜芦醇酯和取代和未取代的芪的方法; 其中每个Y是-O或卤素，每个Z是-O或卤素，每个n和每个m独立地是0,1,2,3,4或5的值，每个A和每个B独立地选自Pn， （2） - （6）碳原子的直链或支链烷基和（3） - （8）碳原子的环烷基，烷氧基，苯基，苄基或 卤素，R独立地选自包含至少一个碳原子的烷基，芳基和芳烷基，Pn是醇保护基团和前述的非对映异构体。 该化合物由多步法制备，包括在碱存在下与苄基卤和苯乙烯偶联配偶体进行N-杂环卡宾型配体偶联。 这些化合物显示出用于食品，化妆品和制药工业的增加的稳定性。