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公开(公告)号：EP2904414A1
公开(公告)日：2015-08-12
申请号：EP13773697.1
申请日：2013-10-02
IPC分类号： G01R33/28 , G01R33/30 , G01R33/381 , G01R33/46
CPC分类号： G01R33/282 , G01R33/307 , G01R33/381 , G01R33/4608
摘要： A method for producing a hyperpolarized sample for use in a magnetic resonance investigation, with the following steps: a) providing a solid sample (50), containing long T1 nuclei and short T1 nuclei in the same molecules (51); b) hyperpolarizing the short T1 nuclei in the solid sample (50), c) transforming the solid sample (50) into a liquid sample (52), d) transferring the polarization of the short T1 nuclei to the long T1 nuclei within the molecules in the liquid sample (52) by Cross Polarization. The invention provides a method which can provide samples with hyperpolarized long T1 nuclei, in particular
13 C or
15 N, in a simple and efficient way.-
公开(公告)号：EP2836849A1
公开(公告)日：2015-02-18
申请号：EP13715681.6
申请日：2013-04-10
发明人： JANNIN, Sami , GIANOTTI, Antonio Giuseppe , LOHMAN, Joost , ENGELKE, Frank , MELZI, Roberto , BORNET, Aurélien , BODENHAUSEN, Geoffrey
CPC分类号： G01R33/282 , G01R33/4608 , G01R33/5605 , G01R33/62
摘要： A method for producing hyperpolarized sample material for use in magnetic resonance investigations involves preparing a target material containing high γ nuclei with a short T1, a polarizing agent with a broad EPR line, and low γ nuclei with a long T1. The polarizing agent in the target material is irradiated with microwave radiation, wherein the target material is at a cryogenic temperature and exposed to a static magnetic field B0≧4.0 T, thus polarizing the high γ nuclei by DNP, and the polarization is transferred from the high γ nuclei to the low γ nuclei by Cross Polarization. A dissolved sample material is prepared containing the hyperpolarized low γ nuclei from the target material. Nuclei with a long longitudinal relaxation time T1 can thereby be quickly hyperpolarized to a high polarization level.
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公开(公告)号：EP2836849B1
公开(公告)日：2016-03-02
申请号：EP13715681.6
申请日：2013-04-10
发明人： JANNIN, Sami , GIANOTTI, Antonio Giuseppe , LOHMAN, Joost , ENGELKE, Frank , MELZI, Roberto , BORNET, Aurélien , BODENHAUSEN, Geoffrey
CPC分类号： G01R33/282 , G01R33/4608 , G01R33/5605 , G01R33/62
摘要： A method for producing hyperpolarized sample material for use in magnetic resonance investigations involves preparing a target material containing high γ nuclei with a short T1, a polarizing agent with a broad EPR line, and low γ nuclei with a long T1. The polarizing agent in the target material is irradiated with microwave radiation, wherein the target material is at a cryogenic temperature and exposed to a static magnetic field B0≧4.0 T, thus polarizing the high γ nuclei by DNP, and the polarization is transferred from the high γ nuclei to the low γ nuclei by Cross Polarization. A dissolved sample material is prepared containing the hyperpolarized low γ nuclei from the target material. Nuclei with a long longitudinal relaxation time T1 can thereby be quickly hyperpolarized to a high polarization level.
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公开(公告)号：EP2904414B1
公开(公告)日：2016-09-07
申请号：EP13773697.1
申请日：2013-10-02
IPC分类号： G01R33/28 , G01R33/30 , G01R33/381 , G01R33/46
CPC分类号： G01R33/282 , G01R33/307 , G01R33/381 , G01R33/4608
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