公开(公告)号：EP2682775B1

公开(公告)日：2016-03-09

申请号：EP13174830.3

申请日：2013-07-03

申请人： Bruker BioSpin GmbH ,  The University of York

发明人： Lohman, Joost A. B. ,  Duckett, Simon Benedict ,  Green, Gary George Reginald ,  Gianotti, Antonio Giuseppe

IPC分类号： G01R33/56 ,  G01R33/28 ,  G01R33/44 ,  G01R33/485 ,  A61B5/055

CPC分类号： G01R33/5601 ,  A61B5/055 ,  G01R33/282 ,  G01R33/445 ,  G01R33/485

公开(公告)号：EP2682775A1

公开(公告)日：2014-01-08

申请号：EP13174830.3

申请日：2013-07-03

申请人： Bruker BioSpin GmbH ,  The University of York

发明人： Lohman, Joost A. B. ,  Duckett, Simon Benedict ,  Green, Gary George Reginald ,  Gianotti, Antonio Giuseppe

IPC分类号： G01R33/56 ,  G01R33/28 ,  G01R33/44 ,  G01R33/485 ,  A61B5/055

CPC分类号： G01R33/5601 ,  A61B5/055 ,  G01R33/282 ,  G01R33/445 ,  G01R33/485

摘要： An NMR experiment on hyperpolarizable magnetic nuclei of substrate molecules in a living human or animal body, with:
a) the substrate molecules are polarized by non-hydrogenating para-hydrogen induced polarization (=NH-PHIP) into a singlet/pseudo singlet state in low magnetic field ;
b) the substrate molecules are injected into the living body, wherein said body or a part thereof is already located inside a magnet at low magnetic field;
c) the magnet is switched on to high magnetic field, and in at least part of the substrate molecules, the singlet state/pseudo singlet state is converted into observable magnetisation;
d) an MRI or MRS measurement is carried out with the living body or the part thereof, collecting data from the substrate molecules.
The NMR experiment is well applicable on hyperpolarized nuclei within a patient, with reduced losses of magnetization due to relaxation processes.

摘要翻译： 在活的人体或动物体内的基质分子的超极化磁核的NMR实验，其具有：a）通过非氢化对氢诱导的极化（= NH-PHIP）将底物分子极化为单重态/伪单态态 低磁场; b）将底物分子注入生物体，其中所述体或其一部分已经位于低磁场的磁体内; c）磁体被接通到高磁场，并且在至少部分衬底分子中，单重态/伪单态态被转换成可观察的磁化; d）用生物体或其部分进行MRI或MRS测量，从底物分子收集数据。 NMR实验非常适用于患者内的超极化核，由于松弛过程，磁化强度降低。