专利检索 ap:("CARNEGIE MELLON UNIVERSITY") AND inv:"HO, Chien" 第 1 页

1.

发明公开
METHODS TO REDUCE TOXICITIES AND TO IMPROVE BIOAVAILABILITIES OF NANODRUGS 审中-公开
标题翻译：减少毒性和提高纳米胶囊生物利用度的方法

公开(公告)号：EP3258917A1

公开(公告)日：2017-12-27

申请号：EP16753050.0

申请日：2016-02-18

申请人： Carnegie Mellon University

发明人： LIU, Li , YE, Qing , HO, Chien

IPC分类号： A61K9/107 , A61K49/06 , A61K9/16

CPC分类号： A61K9/5161 , A61K9/0019 , A61K9/19

摘要： Provided herein are methods for reducing clearance of nanotherapeutic agents from a subject, wherein the methods comprise administering a nutrition supplement to the subject prior to administration of the nanotherapeutic agent in the treatment of a disease. Methods for improving the bioavailability of the nanotherapeutic agent, methods of reducing the toxicity of the nanotherapeutic agent, and kits comprising the nutrition supplement and nanotherapeutic agent are also provided.

2.

发明授权
LOW OXYGEN AFFINITY MUTANT HEMOGLOBIN 失效
标题翻译： MUTANTES血红蛋白低亲和力氧

公开(公告)号：EP0826064B1

公开(公告)日：2004-11-24

申请号：EP96915428.5

申请日：1996-04-30

申请人： CARNEGIE MELLON UNIVERSITY

发明人： HO, Chien , KIM, Hyun-Won , SHEN, Tong-Jian

IPC分类号： C07K14/805 , A61K38/42

CPC分类号： C07K14/805 , A61K38/00

3.

发明公开
LOW OXYGEN AFFINITY MUTANT HEMOGLOBINS 审中-公开
标题翻译：对氧亲和力低血红蛋白突变体

公开(公告)号：EP1294767A1

公开(公告)日：2003-03-26

申请号：EP01946669.7

申请日：2001-06-21

申请人： CARNEGIE MELLON UNIVERSITY

发明人： HO, Chien , TSAI, Ching-Hsuan , FANG, Tsuei-Yun , SHEN, Tong-Jian

IPC分类号： C07K14/805 , C07H17/00 , C12P21/06

CPC分类号： C07K14/805 , A61K38/00

摘要： Non-naturally occurring mutant hemoglobins rHb (bN108Q) and rHb (bL105W) are provided that have a lower oxygen affinity than that of native hemoglobin, but high cooperativity in oxygen binding. rHb (bN108Q) also exhibits enhanced stability against autoxidation. The mutant hemoglobins are preferably produced by recombinant DNA techniques. Such mutanthemoglobins may be used as a component of a blood substitute and hemoglobin therapeutics.

4.

发明公开
LOW OXYGEN AFFINITY MUTANT HEMOGLOBIN 失效
标题翻译： MUTANTES血红蛋白低亲和力氧

公开(公告)号：EP0826064A1

公开(公告)日：1998-03-04

申请号：EP96915428.0

申请日：1996-04-30

申请人： CARNEGIE MELLON UNIVERSITY

发明人： HO, Chien , KIM, Hyun-Won , SHEN, Tong-Jian

IPC分类号： C12N15 , A61K38 , A61P7 , C07K14 , C12N1 , C12P21 , C12R1

CPC分类号： C07K14/805 , A61K38/00

摘要： A non-naturally occurring mutant hemoglobin (α96Val→Trp) is provided that has a lower oxygen affinity than that of native hemoglobin, but high cooperativity in oxygen binding. The mutant hemoglobin is preferably obtained by recombinant DNA techniques. Such a mutant hemoglobin may be used as a component of a blood substitute.