公开(公告)号：EP0817791A1

公开(公告)日：1998-01-14

申请号：EP96912530.0

申请日：1996-03-28

申请人： CASE WESTERN RESERVE UNIVERSITY

发明人： BRANELLEC, Didier ,  WALSH, Kenneth ,  ISNER, Jeffrey, M. ,  DENEFLE, Patrice

IPC分类号： C12N15 ,  A61K9 ,  A61K35 ,  A61K38 ,  A61K48 ,  A61P9 ,  A61P43 ,  C07K14 ,  C12N7

CPC分类号： C07K14/4703 ,  A61K38/00 ,  A61K48/00 ,  C12N2799/022

摘要： The present invention relates to defective recombinant viruses which contain at least one inserted gene encoding all or part of the protein GAX or of a variant of this protein, and to their therapeutic use, in particular for treating post-angioplastic restenosis.

摘要翻译： 本发明涉及缺陷型重组病毒，其包含至少一个插入的编码全部或部分蛋白质GAX或该蛋白质变体的插入基因，并涉及它们的治疗用途，特别是用于治疗血管再狭窄后的再狭窄。

公开(公告)号：EP0754187A1

公开(公告)日：1997-01-22

申请号：EP95912554.0

申请日：1995-02-22

申请人： CASE WESTERN RESERVE UNIVERSITY

发明人： GORSKI, David H., Apartment 401 ,  WALSH, Kenneth

IPC分类号： C12N15 ,  A61K31 ,  A61K38 ,  A61K48 ,  A61P7 ,  A61P9 ,  A61P43 ,  C07H21 ,  C07K14 ,  C12N1

CPC分类号： C07K14/4703 ,  A61K38/00

摘要： A novel growth arrest homeobox gene has been discovered and the nucleotide sequences have been determined in both the rat and the human. The expression of the novel homeobox gene inhibits vascular smooth muscle cell growth. The growth arrest homeobox gene hereinafter referred to as the 'Gax gene' and its corresponding proteins are useful in the study of vascular smooth muscle cell proliferation and in the treatment of blood vessel diseases that result from excessive smooth muscle cell proliferation, particularly after balloon angioplasty.