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公开(公告)号:EP2463307A1
公开(公告)日:2012-06-13
申请号:EP12156473.6
申请日:2006-08-31
申请人: CBIO Limited
发明人: Naylor, Dean Jason , Johnson, Barbara Jane , Dobbin, Caroline Amanda , Howard, Christopher Bruce , Ward, Linda Allison
CPC分类号: C07K14/47 , A61K38/00 , C07K14/4715
摘要: The present invention relates to isolated chaperonin 10 (Cpn10) polypeptides having immunomodulatory activity and one or more amino acid substitutions, deletions and/or additions in the roof β-hairpin region compared to a corresponding wild-type Cpn10 polypeptide.
摘要翻译: 本发明涉及与相应的野生型Cpn10多肽相比,具有免疫调节活性和在屋顶²发夹区域中的一个或多个氨基酸取代,缺失和/或添加的分离的伴侣蛋白10(Cpn10)多肽。
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公开(公告)号:EP2457930A1
公开(公告)日:2012-05-30
申请号:EP12156456.1
申请日:2006-08-31
申请人: CBIO Limited
发明人: Naylor, Dean Jason , Johnson, Barbara Jane , Dobbin, Caroline Amanda , Howard, Christopher Bruce , Ward, Linda Allison
CPC分类号: C07K14/47 , A61K38/00 , C07K14/4715
摘要: The present invention relates to isolated Chaperonin 10 (Cpn10) polypeptides wherein a glycine residue replaces an extra N-terminal alamine residue as compared to a corresponding wild-type Cpn10 polypeptide.
摘要翻译: 本发明涉及分离的伴侣蛋白10(Cpn10)多肽,其中与相应的野生型Cpn10多肽相比,甘氨酸残基替代额外的N-末端阿拉姆残基。
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