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1.发明公开HOMOLOGOUS RECOMBINATION FOR UNIVERSAL DONOR CELLS AND CHIMERIC MAMMALIAN HOSTS 失效对于通用和嵌合供体细胞同源重组哺乳动物细胞。
公开(公告)号：EP0437576A1
公开(公告)日：1991-07-24
申请号：EP90911928.0
申请日：1990-07-25
申请人： CELL GENESYS, INC.
CPC分类号： C12N15/8509 , A01K67/0271 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/025 , A01K2267/03 , C07K14/70539 , C12N15/00
摘要： On emploie la recombinaison homologue afin d'inactiver des gènes, notamment des gènes associés à des antigènes de complexes d'hystocompatibilité majeure (CHM). On a notamment inactivé le gène de beta2-microglobuline afin de réduire ou d'éliminer les antigènes de CHM de la classe A. On peut utiliser les cellules ainsi obtenues en tant que donneuses universelles. De plus, on peut modifier des cellules souche embryonnaires par recombinaison homologue, afin de les utiliser dans la production d'hôtes mammifères chimériques ou transgéniques.
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2.发明授权HOMOLOGOUS RECOMBINATION FOR UNIVERSAL DONOR CELLS AND CHIMERIC MAMMALIAN HOSTS 失效同源重组普遍性和嵌合体供体细胞哺乳动物细胞
公开(公告)号：EP0742723B1
公开(公告)日：2007-06-06
申请号：EP95906116.9
申请日：1994-12-28
发明人： KUCHERLAPATI, Raju , KOLLER, Beverly, H. , SMITHIES, Oliver , DUBRIDGE, Robert, B. , GREENBURG, Gary , CAPON, Daniel, J. , WILLIAMS, Steven, R. , LOURDES ARBONES DE RAFAEL, Maria
CPC分类号： A01K67/0271 , A01K67/0275 , A01K67/0276 , A01K2207/15 , A01K2217/00 , A01K2217/075 , A01K2227/105 , A01K2267/025 , A01K2267/03 , A01K2267/0381 , C07K14/70539 , C12N15/00 , C12N15/8509
摘要： Homologous recombination is employed to inactivate genes, particularly genes associated with MHC antigens. Particularly, the β2-microglobulin gene is inactivated for reducing or eliminating the expression of functional Class I MHC antigens. The resulting cells may be used as universal donor cells. In addition, embryonic stem cells may be modified by homologous recombination for use in producing chimeric or transgenic mammalian hosts, which may be used as source of universal donor organs, or as models for drug and transplantation therapies. Methods for homologous recombination in non-transformed mammalian somatic cells are also described.
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3.发明授权HOMOLOGOUS RECOMBINATION FOR UNIVERSAL DONOR CELLS AND CHIMERIC MAMMALIAN HOSTS 失效通用供体细胞和嵌合哺乳动物宿主的同源重组
公开(公告)号：EP0437576B1
公开(公告)日：2002-07-03
申请号：EP90911928.1
申请日：1990-07-25
申请人： CELL GENESYS, INC.
CPC分类号： C12N15/8509 , A01K67/0271 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/025 , A01K2267/03 , C07K14/70539 , C12N15/00
摘要： Homologous recombination is employed to inactivate genes, particularly genes associated with MHC antigenes. Particularly, the β2-microglobulin gene is inactivated for reducing or eliminating Class I MHC antigenes. The resulting cells may be used as universal donors. In addition, embryonic stem cells may be modified by homologous recombination for use in producing chimeric or transgenic mammalian hosts.
摘要翻译： 采用同源重组来灭活基因，特别是与MHC抗原相关的基因。 特别地，β2-微球蛋白基因失活以减少或消除I类MHC抗原。 得到的细胞可以用作通用供体。 另外，可以通过同源重组修饰胚胎干细胞以用于产生嵌合或转基因哺乳动物宿主。
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4.发明公开HOMOLOGOUS RECOMBINATION FOR UNIVERSAL DONOR CELLS AND CHIMERIC MAMMALIAN HOSTS 失效同源重组普遍性和嵌合体供体细胞哺乳动物细胞
公开(公告)号：EP0742723A1
公开(公告)日：1996-11-20
申请号：EP95906116.0
申请日：1994-12-28
申请人： CELL GENESYS, INC.
发明人： KUCHERLAPATI, Raju , KOLLER, Beverly, H. , SMITHIES, Oliver , DUBRIDGE, Robert, B. , GREENBURG, Gary , CAPON, Daniel, J. , WILLIAMS, Steven, R. , LOURDES ARBONES DE RAFAEL, Maria
CPC分类号： A01K67/0271 , A01K67/0275 , A01K67/0276 , A01K2207/15 , A01K2217/00 , A01K2217/075 , A01K2227/105 , A01K2267/025 , A01K2267/03 , A01K2267/0381 , C07K14/70539 , C12N15/00 , C12N15/8509
摘要： Homologous recombination is employed to inactivate genes, particularly genes associated with MHC antigens. Particularly, the β2-microglobulin gene is inactivated for reducing or eliminating the expression of functional Class I MHC antigens. The resulting cells may be used as universal donor cells. In addition, embryonic stem cells may be modified by homologous recombination for use in producing chimeric or transgenic mammalian hosts, which may be used as source of universal donor organs, or as models for drug and transplantation therapies. Methods for homologous recombination in non-transformed mammalian somatic cells are also described.
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