公开(公告)号：EP1086142B1

公开(公告)日：2002-03-27

申请号：EP99920913.3

申请日：1999-05-25

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)

发明人： DEFAYE, Jacques ,  CROUZY, Serge ,  EVRARD, Nicolas ,  LAW, Ho

IPC分类号： C08B37/16

CPC分类号： C08B37/0012

摘要： The invention concerns a highly region-selective method for preparing a cyclodextrin C-6 monosulphonyl derivative in particular beta -cyclodextrin, which consists in reacting said cyclodextrin with a sulphonylation agent in an aqueous alkaline solution in the presence of a metal salt capable of forming a co-ordinating complex with the cyclodextrin secondary hydroxyl groups, and at the end of the reaction in recuperating said cyclodextrin C-6 monosuphonyl derivative from the reaction mixture. Cyclodextrin monosulphonyl derivatives are particularly useful as starting materials for obtaining monofunctionalised cyclodextrin derivatives.

摘要翻译： 本发明涉及用于制备环糊精C-6单磺酰基衍生物特别是β-环糊精的高度区域选择性方法，其包括使所述环糊精与磺酰化剂在碱金属水溶液中在能够形成 与环糊精仲羟基配位配合物，并在反应结束时从反应混合物中回收所述环糊精C-6单磺酰基衍生物。 环糊精单磺酰基衍生物特别可用作获得单官能化环糊精衍生物的原料。