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1.发明公开
公开(公告)号：EP1673155A2
公开(公告)日：2006-06-28
申请号：EP04817226.6
申请日：2004-10-13
IPC分类号： B01D1/00
CPC分类号： C07K14/805
摘要： The invention relates to a method of dissociating the extracellular haemoglobin molecule of annelids, e.g. Arenicola marina, which can be used to obtain the protein chains forming said molecule. The inventive method is characterised in that it comprises a step consisting in bringing an extracellular haemoglobin sample from annelids, e.g. Arenicola marina, into contact with at least one dissociating agent, e.g. a mixture containing dithiothreitol (DTT) or tris(2-carboxyethyl)phosphine (TCEP) hydrochloride or beta-mercaptoethanol and a dissociation buffer for a sufficient length of time in order to separate the protein chains from one another.
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2.发明授权UTILISATION COMME SUBSTITUT SANGUIN D'UNE HEMOGLOBINE EXTRACELLULAIRE DE POIDS MOLECULAIRE ELEVE 有权使用细胞外血红蛋白较高分子量的AS血液代用品
公开(公告)号：EP1284994B1
公开(公告)日：2004-07-28
申请号：EP01936553.5
申请日：2001-05-17
发明人： ZAL, Franck , TOULMOND, André , LALLIER, François
IPC分类号： C07K14/435 , A61K38/42 , C07K14/805
CPC分类号： C07K14/805 , C07K14/43536
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3.发明授权
公开(公告)号：EP1976865B1
公开(公告)日：2012-11-14
申请号：EP07704085.5
申请日：2007-01-23
发明人： ZAL, Franck , ROUSSELOT, Morgane
IPC分类号： C07K14/805 , C07K14/41 , C07K14/435 , A61K38/42
CPC分类号： C07K14/805 , A61K38/42
摘要： The present invention relates to the use of a high molecular weight extracellular hemoglobin for the manufacture of a medicament for treating and/or preventing diseases by inhibition of calcium. Advantageously, the extracellular hemoglobin is obtained from Annelids. In particular, the invention concerns the use of a high molecular weight extracellular hemoglobin for the manufacture of a medicament for treating and/or preventing cardiovascular diseases, such as hypertension, angina such as angina pectoris, Raynaud's disease, arteriopathy, tachycardia, vasospasm, ischemia, myocardial infarction, congestive heart failure, arrhythmia or cerebrovacular accident.
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4.发明授权
公开(公告)号：EP1673155B1
公开(公告)日：2012-08-22
申请号：EP04817226.6
申请日：2004-10-13
IPC分类号： B01D1/00
CPC分类号： C07K14/805
摘要： The invention relates to a method of dissociating the extracellular haemoglobin molecule of annelids, e.g. Arenicola marina, which can be used to obtain the protein chains forming said molecule. The inventive method is characterised in that it comprises a step consisting in bringing an extracellular haemoglobin sample from annelids, e.g. Arenicola marina, into contact with at least one dissociating agent, e.g. a mixture containing dithiothreitol (DTT) or tris(2-carboxyethyl)phosphine (TCEP) hydrochloride or beta-mercaptoethanol and a dissociation buffer for a sufficient length of time in order to separate the protein chains from one another.
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5.发明公开
公开(公告)号：EP1976865A1
公开(公告)日：2008-10-08
申请号：EP07704085.5
申请日：2007-01-23
发明人： ZAL, Franck , ROUSSELOT, Morgane
IPC分类号： C07K14/00
CPC分类号： C07K14/805 , A61K38/42
摘要： The present invention relates to the use of a high molecular weight extracellular hemoglobin for the manufacture of a medicament for treating and/or preventing diseases by inhibition of calcium. Advantageously, the extracellular hemoglobin is obtained from Annelids. In particular, the invention concerns the use of a high molecular weight extracellular hemoglobin for the manufacture of a medicament for treating and/or preventing cardiovascular diseases, such as hypertension, angina such as angina pectoris, Raynaud's disease, arteriopathy, tachycardia, vasospasm, ischemia, myocardial infarction, congestive heart failure, arrhythmia or cerebrovacular accident.
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