公开(公告)号：EP1941279B1

公开(公告)日：2014-10-22

申请号：EP06807674.4

申请日：2006-10-30

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

发明人： SCHERMAN, Daniel ,  BESSODES, Michel ,  CHANEAC, Corinne ,  GOURIER, Didier, Louis ,  JOLIVET, Jean-Pierre ,  LE MASNE DE CHERMONT, Quentin ,  MAITREJEAN, Serge ,  PELLE, Fabienne, Julie

IPC分类号： G01N33/58 ,  A61K49/00

CPC分类号： G01N33/587 ,  A61K49/0067 ,  B82Y15/00

公开(公告)号：EP1941279A1

公开(公告)日：2008-07-09

申请号：EP06807674.4

申请日：2006-10-30

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

发明人： SCHERMAN, Daniel ,  BESSODES, Michel ,  CHANEAC, Corinne ,  GOURIER, Didier, Louis ,  JOLIVET, Jean-Pierre ,  LE MASNE DE CHERMONT, Quentin ,  MAITREJEAN, Serge ,  PELLE, Fabienne, Julie

IPC分类号： G01N33/58 ,  A61K49/00

CPC分类号： G01N33/587 ,  A61K49/0067 ,  B82Y15/00

摘要： The invention relates to using persistent luminescence nanoparticles, functionalised if necessary, in the form of an diagnosis agent for an in vivo optical imaging. Said nanoparticles are preferably consist of a compound selected from a group comprising (1) silicates, aluminates, aluminosilicates, germanates, titanates, oxysulphides, phosphates and vanadates, wherein said compounds contain at least one type of metal oxide, (2) the sulphides comprise at least one metal ion selected from zinc, strontium and calcium, and (3) metal oxides, wherein said compounds is doped with at least one rare earth ion, and possibly with at least one transition metal ion. In a preferred embodiment, the diagnosis agent is used for an organism vascularisation imaging. A method and kit for detecting or quantifying in vitro a substance of biological or chemical interest in a sample by using said pre-functionalised nanoparticles are also disclosed. .