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1.发明授权NEW SUPPORTED OXIDATION REACTANTS, PROCESS FOR THEIR PREPARATION AND USES THEREOF 有权新的支持氧化反应，方法及其及其应用
公开(公告)号：EP2035442B1
公开(公告)日：2011-10-12
申请号：EP07765429.1
申请日：2007-06-14
发明人： MARTINEZ, Jean , SUBRA, Gilles , CRISTAU, Michèle , CANTEL, Sonia
CPC分类号： C07K1/1133 , Y02P20/55 , Y02P20/582
摘要： The present invention relates to a supported oxidation reactant of formula (I): R-[Met(O)k]n-X- (I) in which: - R represents a hydrogen atom or an amine function-protecting group, -[Met(O)] represents an oxidized methionine residue of formula - k is 1 or 2 - represents a solid or soluble support used in organic synthesis, - X represents a radical derived from a function of the type amine or hydroxyl, or halogeno, capable of anchoring methionine, it being understood that this function capable of anchoring methionine can be separated from the support by means of a functionalized arm or a spacer, and - n is an integer greater than or equal to 1. The invention also relates to the use of a supported oxidation reactant of formula (I), for the formation of intramolecular disulfide bridges, in particular in peptides and/or proteins.
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2.发明公开NEW SUPPORTED OXIDATION REACTANTS, PROCESS FOR THEIR PREPARATION AND USES THEREOF 有权新的支持氧化反应，方法及其及其应用
公开(公告)号：EP2035442A1
公开(公告)日：2009-03-18
申请号：EP07765429.1
申请日：2007-06-14
发明人： MARTINEZ, Jean , SUBRA, Gilles , CRISTAU, Michèle , CANTEL, Sonia
CPC分类号： C07K1/1133 , Y02P20/55 , Y02P20/582
摘要： The present invention relates to a supported oxidation reactant of formula (I): R-[Met(O)k]n-X- (I) in which: - R represents a hydrogen atom or an amine function-protecting group, -[Met(O)] represents an oxidized methionine residue of formula - k is 1 or 2 - represents a solid or soluble support used in organic synthesis, - X represents a radical derived from a function of the type amine or hydroxyl, or halogeno, capable of anchoring methionine, it being understood that this function capable of anchoring methionine can be separated from the support by means of a functionalized arm or a spacer, and - n is an integer greater than or equal to 1. The invention also relates to the use of a supported oxidation reactant of formula (I), for the formation of intramolecular disulfide bridges, in particular in peptides and/or proteins.
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