专利检索 ap:("CENTRE NATIONAL DELA RECHERCHE SCIENTIFIQUE (CNRS)") AND inv:"BES, Cédric" 第 1 页

1.

发明公开
FRAGMENTS FAB MUTANS DE L'ANTICORPS ANTI-CD4 CHIMERE 13B8.2 ET LEURS APPLICATIONS 有权
标题翻译：嵌合抗CD4抗体13B8.2和使用的突变体Fab片段

公开(公告)号：EP1519960A2

公开(公告)日：2005-04-06

申请号：EP03755580.2

申请日：2003-07-07

申请人： CENTRE NATIONAL DELA RECHERCHE SCIENTIFIQUE (CNRS)

发明人： DEVAUX, Christian,361, rue du Pré aux Clercs , BES, Cédric , BRIANT-LONGUET, Laurence , CERUTTI, Martine , DEVAUCHELLE, Gérard , CHARDES, Thierry , GRANIER, Claude , PAU, Bernard

IPC分类号： C07K16/28 , A61K39/395 , A61P17/06 , A61P31/18 , A61P35/00 , A61P37/06

CPC分类号： C07K16/2812 , A61K2039/505 , C07K2317/55

摘要： The invention is related to the field of immunotherapy, and concerns novel ligands for the CD4 molecule, mutant Fab 13B8.2 fragments of the CD4 antibody binding the CD4 molecule and comprising a mutation of at least one residue in a position located in the variable domain VH of the heavy chain and/or in a position located in the variable domain Vλ of the light chain. The invention also concerns pharmaceutical compositions containing said ligands for treating pathologies wherein the CD4 molecule is involved.