公开(公告)号：EP1787653A2

公开(公告)日：2007-05-23

申请号：EP05762122.9

申请日：2005-07-05

申请人： CENTRO DE INGENIERIA GENETICA Y BIOTECNOLOGIA (CIGB)

发明人： ABRAHANTES PEREZ, María del Carmen, Calle 186 ,  REYES GONZÁLEZ, Jesús, Calle 186 ,  VELIZ RÍOS, Gloria, Calle 140 ,  MARTÍNEZ DÍAZ, Eduardo, Calle 186 ,  GASMURI GONZÁLEZ, Caridad Anais ,  GARCÍA SUÁREZ, José, Calle 186 ,  BEQUET ROMERO, Mónica ,  GONZÁLEZ LÓPEZ, Luis Javier, Calle 186 ,  CASTELLANOS SERRA, Lila Rosa, Kohly 51. ,  SELMAN-HOUSEIN SOSA, Manuel ,  GÓMEZ RIERA, Raúl ,  GAVILONDO COWLEY, Jorge Victor, Calle G

IPC分类号： A61K38/16 ,  C07K14/265 ,  A61P35/00 ,  A61P31/04

CPC分类号： A61K38/16

摘要： The present invention is related to a composition capable of inhibiting the growth of tumoral cells of different histological origins and of activated endothelial cells. The components of said compositions are polypeptide fragments of the serralisins, corresponding to the C-terminal fragment, from the internal metionine trough the end of the molecule, which could be combined among them and optionally with the prodigiosins that potentiate the antitumoral effect of the composition. The prodigiosins in the composition could be at a concentration of 0.1 - 100 nM. The anti-proliferative action of this composition is mediated by apoptotic mechanism. It's "in vivo" administration has antitumoral, antiangiogenic and protective effect against malignant tumors.

摘要翻译： 本发明涉及能够抑制不同组织起源和活化的内皮细胞的肿瘤细胞生长的组合物。 所述组合物的组分是对应于来自分子末端的内部甲硫氨酸的对应于C末端片段的血清素的多肽片段，其可以在它们之间并且任选地与促进组合物的抗肿瘤作用的生殖细胞因子组合 。 组合物中的生殖细胞可以是0.1-100nM的浓度。 该组合物的抗增殖作用由凋亡机制介导。 “体内”治疗对恶性肿瘤具有抗肿瘤，抗血管生成和保护作用。

公开(公告)号：EP1787653B1

公开(公告)日：2012-06-06

申请号：EP05762122.9

申请日：2005-07-05

申请人： CENTRO DE INGENIERIA GENETICA Y BIOTECNOLOGIA (CIGB)

发明人： ABRAHANTES PEREZ, María del Carmen, Calle 186 ,  REYES GONZÁLEZ, Jesús, Calle 186 ,  VELIZ RÍOS, Gloria, Calle 140 ,  MARTÍNEZ DÍAZ, Eduardo, Calle 186 ,  GASMURI GONZÁLEZ, Caridad Anais ,  GARCÍA SUÁREZ, José, Calle 186 ,  BEQUET ROMERO, Mónica ,  GONZÁLEZ LÓPEZ, Luis Javier, Calle 186 ,  CASTELLANOS SERRA, Lila Rosa, Kohly 51. ,  SELMAN-HOUSEIN SOSA, Manuel ,  GÓMEZ RIERA, Raúl ,  GAVILONDO COWLEY, Jorge Victor, Calle G

IPC分类号： A61K38/16 ,  C07K14/265 ,  A61P35/00 ,  A61P31/04

CPC分类号： A61K38/16

摘要： The invention relates to a composition that can inhibit the growth of tumour cells of different histological origins and activated endothelial cells. The components of said composition are polypeptide fragments of serralysins, corresponding to the C-terminal fragment, from the internal methionine of the sequence to the end of the molecule, which can be combined with one another and, optionally, with prodigiosins which potentiate the anti-tumour effect of the composition. The prodigiosins in the composition can be at a concentration of between 0.1 - 100 nM. The anti-proliferative action of the composition is provided by apoptotic mechanisms. The in vivo administration of the inventive composition has an anti-tumour effect, an anti-angiogenic effect and protects against malignant tumours.