公开(公告)号：EP2462942A4

公开(公告)日：2013-03-06

申请号：EP10806533

申请日：2010-08-05

申请人： CHEMO SERO THERAPEUT RES INST ,  UNIV KUMAMOTO NAT UNIV CORP ,  GINKYO ACADEMY KUMAMOTO HEALTH SCIENCE UNIVERSITY

发明人： KAMEI SHINTARO ,  SHINDOME ASAMI ,  HAMAMOTO TAKAYOSHI ,  MAEDA HIROAKI ,  HIRASHIMA MASAKI ,  OKUDA SACHIO ,  UMEHASHI MISAKO ,  OGAWA SACHIE ,  IMUTA MEGUMI ,  AKAIKE NORIO ,  TAKAHAMA KAZUO ,  WADA RYOKO

IPC分类号： A61K38/48 ,  A61P11/00 ,  A61P11/14

CPC分类号： C12N9/6443 ,  A61K38/4846

公开(公告)号：EP1544293A4

公开(公告)日：2006-03-15

申请号：EP03798512

申请日：2003-09-25

申请人： CHEMO SERO THERAPEUT RES INST

发明人： SOEJIMA KENJI ,  MIMURA NORIKO ,  MAEDA HIROAKI ,  NOZAKI CHIKATERU ,  HAMAMOTO TAKAYOSHI ,  NAKAGAKI TOMOHIRO

IPC分类号： A61P7/02 ,  C07K16/40 ,  C12N9/64 ,  C12N15/02 ,  C12P21/08 ,  A61K38/43 ,  A61K39/395 ,  C12N5/10 ,  G01N33/532 ,  G01N33/573 ,  G01N33/577

CPC分类号： C12N9/6489 ,  C07K16/40

摘要： It is intended to provide an antibody showing a selective immunoreactivity for ADAMTS-13 and employ this antibody in epitope analysis or diagnosis of an ADAMTS-13 autoantibody-positive patient. Moreover, it is intended to provide a process for producing a modified ADAMTS-13 molecule having a partial deletion aiming at the application thereof to drugs and use thereof. Namely, an antibody specific for ADAMTS-13 which can be obtained from a warm-blooded animal immunologically sensitized with a polypeptide containing the whole ADAMTS-13 amino acid sequence or a part thereof; a process for producing an antibody involving the step of immunologically sensitizing a warm-blooded animal with a polypeptide containing the whole ADAMTS-13 amino acid sequence or a part thereof; use of the above-described antibody involving a method of detecting ADAMTS-13 and a purification method; and a modified ADAMTS-13 molecule having a partial deletion.