公开(公告)号：EP2944330A4

公开(公告)日：2016-09-07

申请号：EP13871129

申请日：2013-12-17

申请人： CHEMO SERO THERAPEUT RES INST

发明人： SHINYA NORIKO ,  UCHIDA TAKANORI ,  KISHIDA AKIO ,  HIGAMI TETSUYA

IPC分类号： A61L27/36 ,  A61F2/06

CPC分类号： A61F2/82 ,  A61F2/06 ,  A61F2/062 ,  A61F2230/0069 ,  A61F2240/002 ,  A61L27/3625 ,  A61L27/3683 ,  A61L27/507 ,  A61L27/54 ,  A61L2300/252 ,  Y10T156/1038 ,  A61L27/34 ,  C08L89/00

摘要： An artificial blood vessel that can be transplanted to blood vessels with a small diameter, can be adjusted to an arbitrary size of a diameter, improves in invasiveness when a graft is taken, and overcomes the problem on the provision of a graft is provided. An artificial blood vessel prepared from a decellularized tubular structure, which is prepared by processing a decellularized, sheet-like blood vessel (decellularized blood vessel sheet) into a roll structure, and a tissue adhesive, wherein a portion which is contacted with blood that flows within the artificial blood vessel consists of the tissue of the tunica intima lined with the tissue of the tunica media whereas a portion of the sheet that overlaps when the sheet is processed into a roll structure (overlap width) consists of the tissue of the tunica media and wherein a tissue adhesive is applied to the overlap width.

摘要翻译： 可以移植到具有小直径的血管的人造血管可以调节到任意尺寸的直径，提高移植物时的侵入性，并且克服了提供移植物的问题。 由脱细胞化的管状结构制备的人造血管，其通过将脱细胞化的片状血管（脱细胞血管片）加工成辊结构而制备，以及组织粘合剂，其中与血液接触的部分 在人造血管内部由内膜内膜与中膜的组织组成，而当片材加工成辊结构（重叠宽度）时与片材重叠的部分片材由中膜的组织组成 并且其中将组织粘合剂施加到所述重叠宽度。