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公开(公告)号：EP2570403A4
公开(公告)日：2013-10-09
申请号：EP10851187
申请日：2010-05-14
发明人： HE KUNLUN , LI SONG , ZHONG WU , LIU JUAN , WANG LILI , LI XIN , HU GUOLIANG , LONG LONG , XIAO JUNHAI , ZHENG ZHIBING , LI WEI , LI RUIJUN , LIU CHUNLEI , BAI JIE
IPC分类号： C07C275/24 , A61K31/17 , A61K31/381 , A61K31/425 , A61K31/4706 , A61P9/00 , A61P43/00 , C07C275/26 , C07C275/28 , C07D215/40 , C07D275/02 , C07D277/02 , C07D333/04 , C07D333/10
CPC分类号： C07C275/28 , C07D215/40
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2.发明公开ACRYLAMIDE COMPOUNDS AND USE THEREOF FOR INHIBITING APOPTOSIS 有权ACRYLAMIDVERBINDUNGEN UND IHRE VERWENDUNG ZUR HEMMUNG VON APOPTOSE
公开(公告)号：EP2573078A4
公开(公告)日：2013-11-20
申请号：EP10851188
申请日：2010-05-14
发明人： HE KUNLUN , LI SONG , ZHONG WU , LIU JUAN , WANG LILI , LI XIN , HU GUOLIANG , WANG JIE , LONG LONG , XIAO JUNHAI , ZHENG ZHIBING , LI WEI , LI RUIJUN , LIU CHUNLEI , TANG JIE
IPC分类号： C07D333/04 , A61K31/17 , A61K31/381 , A61K31/435 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61P9/00 , A61P43/00 , C07C335/12 , C07D295/21 , C07D333/10 , C07D409/12
CPC分类号： A61K31/18 , A61K31/17 , A61K31/381 , A61K31/435 , A61K31/4453 , A61K31/4709 , A61K31/496 , A61K31/5375 , A61K31/5377 , C07C335/12 , C07D295/194 , C07D295/21 , C07D333/24 , C07D409/12
摘要： The present invention relates to a compound of Formula I, or an isomer, pharmaceutically acceptable salt and solvate thereof; the present invention also relates to a composition comprising a compound of Formula I, or an isomer, pharmaceutically acceptable salt and solvate thereof, and a pharmaceutically acceptable carrier, excipient or diluents. The present invention also relates to use of a compound of Formula I, or an isomer, pharmaceutically acceptable salt and solvate thereof for combating apoptosis, preventing or treating a disease or disorder associated with apoptosis; especially use for protecting cardiomyocyte, preventing or treating a disease or disorder associated with cardiomyocyte apoptosis.
摘要翻译： 本发明涉及式I化合物或其异构体，药学上可接受的盐和溶剂合物; 本发明还涉及包含式I化合物或其异构体，药学上可接受的盐和溶剂化物以及药学上可接受的载体，赋形剂或稀释剂的组合物。 本发明还涉及式I化合物或其异构体，药学上可接受的盐和溶剂合物在抗凋亡，预防或治疗与细胞凋亡相关的疾病或病症中的用途; 特别用于保护心肌细胞，预防或治疗与心肌细胞凋亡相关的疾病或病症。
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3.发明公开(2E)-3-PHENYL-N-[2,2,2-TRIFLUORO-1-[[(8-QUINOLINEAMINO)THIOMETHYL]AMINO]ETHYL]-2-ACRYLAMIDE AND PHARMACEUTICAL USES THEREOF 有权（2E）-3-苯基-N- [2,2,2-三氟-1 - [[（8- CHINOLINAMINO）硫代甲基]氨基]乙基] -2-丙烯酰胺及其药物用途
公开(公告)号：EP2589593A4
公开(公告)日：2013-11-06
申请号：EP10851189
申请日：2010-05-14
发明人： HE KUNLUN , LI SONG , WANG LILI , LI XIN , ZHONG WU , HU GUOLIANG , WANG JIE , LI RUIJUN , LIU CHUNLEI , XIAO JUNHAI , LONG LONG , LI WEI , CHEN HUA
IPC分类号： C07D215/38 , A61K31/47 , A61P9/00 , C07D215/40
CPC分类号： C07D215/40 , A61K31/47
摘要： The present invention relates to an acrylamide compound of Formula I, or an isomer, pharmaceutically acceptable salt and solvate thereof, to a composition comprising the compound or an isomer, pharmaceutically acceptable salt and solvate thereof, and a pharmaceutically acceptable carrier, excipient or diluent, and to a use of the compound or the composition for prophylaxis and/or treatment of a disease or disorder associated with cardiomyocyte apoptosis
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