公开(公告)号：EP0549702B1

公开(公告)日：2000-03-15

申请号：EP91917632.1

申请日：1991-08-23

申请人： CHIRON CORPORATION

发明人： RALPH, Peter ,  CHONG, Kong, T. ,  DEVLIN, James ,  ZIMMERMAN, Robert ,  AUKERMAN, Sharon, Lea ,  RING, David, B. ,  MA, Sylvia, Hsieh

IPC分类号： A61K38/19

CPC分类号： A61K38/193 ,  A61K31/70 ,  A61K31/41 ,  A61K31/505 ,  A61K31/495 ,  A61K31/415 ,  A61K2300/00

摘要： A colony stimulating factor, CSF-1, is a lymphokine useful in treating or preventing bacterial, viral or fungal infections, neoplasms, leukopenia, wounds, and in overcoming the immunosuppression induced by chemotherapy or resulting from other causes. CSF-1 is obtained in usable amounts by recombinant methods, including cloning and expression of the murine and human DNA sequences encoding this protein.