专利检索 ap:("CHIRON CORPORATION" OR "CHILDREN'S HOSPITAL MEDICAL CENTER OF NORTHERN CALIFORNIA") AND inv:"GRANOFF, Dan" 第 1 页

1.

发明授权
MONOCLONAL ANTIBODIES THAT DEFINE UNIQUE MENINGOCOCCAL B EPITOPES AND THEIR USE IN THE PREPARATION OF VACCINE COMPOSITIONS 失效
标题翻译：脑膜炎球菌B-表位形成的单克隆抗体及其使用疫苗组合物的制造

公开(公告)号：EP0922059B1

公开(公告)日：2003-10-22

申请号：EP97941371.3

申请日：1997-08-27

申请人： CHIRON CORPORATION , CHILDREN'S HOSPITAL MEDICAL CENTER OF NORTHERN CALIFORNIA

发明人： GRANOFF, Dan , MOE, Gregory, R.

IPC分类号： C07K16/12 , A61K39/095 , C12N5/12 , G01N33/50 , C07K16/42 , C07K7/06 , A61K38/08

CPC分类号： C07K14/22 , A61K39/00 , A61K2039/505 , C07K16/1217 , C07K2317/34 , G01N33/56911 , G01N2333/22 , Y10S514/898 , Y10S530/807 , Y10S530/808

摘要： Novel bactericidal antibodies against Neisseria meningitidis serogroup B ('MenB') are disclosed. The antibodies either do not cross-react or minimally cross-react with host tissue polysialic acid and hence pose minimal risk of autoimmune activity. The antibodies are used to identify molecular mimetics of unique eptitopes found on MenB or E. coli K1. Examples of such peptide mimetics are described that elicit serum antibody capable of activating complement-mediated bacteriolysis of MenB. Vaccine compositions containing such mimetics can be used to prevent MenB or E. coli K1 disease without the risk of evoking autoantibody.

2.

发明公开
MONOCLONAL ANTIBODIES THAT DEFINE UNIQUE MENINGOCOCCAL B EPITOPES AND THEIR USE IN THE PREPARATION OF VACCINE COMPOSITIONS 失效
标题翻译：脑膜炎球菌B-表位形成的单克隆抗体及其使用疫苗组合物的制造

公开(公告)号：EP0922059A1

公开(公告)日：1999-06-16

申请号：EP97941371.0

申请日：1997-08-27

申请人： CHIRON CORPORATION

发明人： GRANOFF, Dan , MOE, Gregory, R.

IPC分类号： C12N15 , A61K39 , A61P31 , C07K7 , C07K14 , C07K16 , C12N5 , C12P21 , G01N33

CPC分类号： C07K14/22 , A61K39/00 , A61K2039/505 , C07K16/1217 , C07K2317/34 , G01N33/56911 , G01N2333/22 , Y10S514/898 , Y10S530/807 , Y10S530/808

摘要： Novel bactericidal antibodies against Neisseria meningitidis serogroup B ('MenB') are disclosed. The antibodies either do not cross-react or minimally cross-react with host tissue polysialic acid and hence pose minimal risk of autoimmune activity. The antibodies are used to identify molecular mimetics of unique eptitopes found on MenB or E. coli K1. Examples of such peptide mimetics are described that elicit serum antibody capable of activating complement-mediated bacteriolysis of MenB. Vaccine compositions containing such mimetics can be used to prevent MenB or E. coli K1 disease without the risk of evoking autoantibody.

3.

发明公开
MOLECULAR MIMETICS OF MENINGOCOCCAL B EPITOPES WHICH ELICIT FUNCTIONALLY ACTIVE ANTIBODIES 有权
标题翻译：脑膜炎双球菌乙表位的单克隆抗体分子模仿

公开(公告)号：EP1379272A2

公开(公告)日：2004-01-14

申请号：EP02721722.3

申请日：2002-04-11

申请人： CHIRON CORPORATION , Children's Hospital Oakland Research Institute

发明人： GRANOFF, Dan , MOE, Gregory , RAPPUOLI, Rino

IPC分类号： A61K39/095 , C12Q1/68 , C12P19/34 , C07H21/02 , C07H21/04

CPC分类号： C07K14/22 , A61K39/00 , A61K2039/505 , Y10S530/825

摘要： Molecular mimetics of a surface-exposed epitope on loop 4 of PorA of Neisseria meningitidis serogroup B (MenB) P1.2 serosubtype and antibodies produced against the same are disclosed. Compositions containing such molecular mimetics or the antibodies thereto can be used to prevent MenB disease, as well as for diagnosis of MenB infection.