公开(公告)号：EP1589101A4

公开(公告)日：2006-01-18

申请号：EP03768371

申请日：2003-12-26

申请人： CHUGAI PHARMACEUTICAL CO LTD ,  TOUDAI TLO LTD

发明人： ABURATANI HIROYUKI ,  ITO HIROTAKA ,  ISHIKAWA SHUNPEI ,  FUKUMOTO SHINICHI

IPC分类号： C07K14/705 ,  G01N33/574 ,  C12N15/09 ,  G01N33/53

CPC分类号： G01N33/57423 ,  C07K14/705

摘要： It is intended to provide a novel protein showing overexpression specifically in an abnormal cell or an abnormal tissue; a diagnostic method and a diagnostic kit for a disease in which the overexpression of a gene encoding the above protein participates; and a screening method and a screening kit for a preventive/remedy for a disease in which the overexpression of a gene encoding the above protein participates. To achieve these objects, there is provided a novel protein showing overexpression specifically in an abnormal cell or an abnormal tissue which is: (a) a protein comprising the amino acid sequence represented by SEQ ID NO:2, or (b) a protein comprising an amino acid sequence derived from the amino acid sequence represented by SEQ ID NO:2 by deletion, substitution or addition of one or more amino acids and showing overexpression specifically in an abnormal cell or an abnormal tissue. The expression level of a gene encoding this protein is employed as an indication in diagnosing a disease. Also, an effect of lowering the expression level of the gene encoding this protein is employed as an indication in screening a preventive/remedy for a disease.