公开(公告)号：EP4104857A1

公开(公告)日：2022-12-21

申请号：EP21754475.8

申请日：2021-02-10

申请人： CHUGAI SEIYAKU KABUSHIKI KAISHA

发明人： SAKURAI, Mika ,  NARITA, Yoshinori ,  TANIGUCHI, Kenji ,  MIKAMI, Hirofumi ,  HORIKAWA, Sayuri ,  UCHIKAWA, Ryo ,  ONO, Natsuki ,  HAMADA, Koki

IPC分类号： A61K39/395 ,  A61K45/00 ,  A61P35/00 ,  A61P43/00 ,  C07K16/28 ,  C07K16/30 ,  C07K16/46 ,  C12N15/13

摘要： An objective of the present disclosure is to provide: anticancer agents having an immune cell-activating effect, a cytotoxic activity, or an antitumor activity, but having a low effect on non-tumor tissues such as normal tissues and having few side effects; combination therapies using those anticancer agents and other anticancer agents; and pharmaceutical combinations for use in those combination therapies.
Anticancer agents expected to be applied to various types of cancers, which have an immune cell-activating effect, a cytotoxic activity, or an antitumor activity while having a low effect on non-tumor tissues such as normal tissues and having few side effects by using as an active ingredient an anti-CD 137 antigen-binding molecule of the present disclosure, the binding activity of which to CD137 changes depending on various substances (for example, low molecular weight compounds) in target tissues, are provided. Combination therapies using those anticancer agents and other anticancer agents, and pharmaceutical compositions for use in those combination therapies are also provided.