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13 条记录 (耗时 0.014 秒)

    Fucose Transporter
    1.
    发明公开
    Fucose Transporter 审中-公开
    岩藻糖转运蛋白

    公开(公告)号：EP2228445A1

    公开(公告)日：2010-09-15

    申请号：EP10163960.7

    申请日：2004-06-18

    申请人： Chugai Seiyaku Kabushiki Kaisha

    发明人： Tsuchiya, Masayuki ,  Iijima, Shigeyuki ,  Sugo, Izumi ,  Sekimori, Yasuo ,  Ueno, Kenju ,  Habu, Kiyoshi

    IPC分类号： C12N15/11 ,  C12N15/00 ,  C12N5/10 ,  C12Q1/68 ,  G01N33/53 ,  C12P21/02 ,  C12P21/08

    CPC分类号： C07K14/47 ,  C12P21/005 ,  G01N2500/00

    摘要： The present invention provides a gene encoding a fucose transporter, a fucose transporter polypeptide, a method for screening for a compound that binds to a fucose transporter or a compound that inhibits fucose transport activity, a cell having inhibited fucose transporter functions, and a cell wherein the expression of the fucose transporter is inhibited. The present invention further relates to a method for producing recombinant protein, and specifically, to a method for producing protein by which fucose existing within the Golgi apparatus of a host cell is decreased, a method for inhibiting the addition of fucose to protein by which fucose existing within the Golgi apparatus of a host cell is decreased upon production of recombinant protein using the host cell, a method for increasing the cytotoxic activity of an antibody by which an antibody is produced using a cell wherein fucose existing within the Golgi apparatus is decreased, and a cell having a Golgi apparatus wherein fucose existing within the Golgi apparatus is deceased.

    摘要翻译： 本发明提供编码岩藻糖转运蛋白，岩藻糖转运蛋白多肽，筛选结合岩藻糖转运蛋白的化合物或抑制岩藻糖转运活性的化合物的方法，具有抑制岩藻糖转运蛋白功能的细胞的基因，以及细胞，其中 岩藻糖转运蛋白的表达被抑制。 本发明还涉及一种生产重组蛋白质的方法，具体地说涉及一种生物蛋白质的制造方法，其中存在于宿主细胞高尔基体内的岩藻糖减少，一种抑制岩藻糖添加岩藻糖蛋白质的方法 在使用宿主细胞产生重组蛋白质时，存在于宿主细胞的高尔基体内的存在的方法，使用其中存在于高尔基体中的岩藻糖减少的细胞增加抗体产生抗体的方法， 以及具有高尔基体的细胞，其中存在于高尔基体内的岩藻糖已经死亡。

    Blood-borne non-A, non-B hepatitis specific protein, DNA encoding it, and process for its production
    6.
    发明公开
    Blood-borne non-A, non-B hepatitis specific protein, DNA encoding it, and process for its production 失效
    非肠道非B型肝炎特异性蛋白质，Dafürkodierende DNS和Verfahren zu seiner Herstellung。

    公开(公告)号：EP0416725A2

    公开(公告)日：1991-03-13

    申请号：EP90307566.1

    申请日：1990-07-11

    申请人： Chugai Seiyaku Kabushiki Kaisha ,  Arima, Terukatsu

    发明人： Arima, Terukatsu ,  Yamamoto, Osamu ,  Tsuchiya, Masayuki ,  Oshima, Masanobu

    IPC分类号： C12N15/51 ,  C07K15/00

    CPC分类号： C07K14/005 ,  A61K39/00 ,  C12N2770/24222

    摘要： A DNA coding for a blood-borne non-A, non-B hepatitis specific antigenic protein and corresponding to an RNA directly isolated from a human blood or liver tissue is disclosed. This antigenic protein can be produced by using the DNA, and the antigenic protein binds to a antibody in the serum of the patient with the non-A, non-B hepatitis. Therefore, the antigenic protein is useful for the diagnostic measurement of an antibody against the non-A, non-B hepatitis specific antigen.

    摘要翻译： 公开了编码血液非A非乙型肝炎特异性抗原蛋白并对应于从人血液或肝组织直接分离的RNA的DNA。 该抗原蛋白可以通过使用DNA产生，抗原蛋白与非A非乙型肝炎患者血清中的抗体结合。 因此，抗原蛋白质可用于诊断测定抗A非乙型肝炎特异性抗原的抗体。